Natural Aging Increases Focused Ultrasound-Induced Blood-Brain Barrier Opening in Wild-Type Mice

被引：1

作者：

Noel, Rebecca L. ^{[1
]}

Ji, Robin ^{[1
]}

Batts, Alec J. ^{[1
]}

Kline-Schoder, Alina ^{[1
]}

Pouliopoulos, Antonios N. ^{[1
]}

Konofagou, Elisa E. ^{[1
]}

机构：

[1] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA

来源：

INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021) | 2021年

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Focused Ultrasound; Blood-Brain Barrier; microbubbles; cavitation; natural aging; DISEASE;

D O I：

10.1109/IUS52206.2021.9593523

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Focused Ultrasound (FUS) paired with systemically-introduced microbubbles (MB) is a widely-used noninvasive technique for transiently opening the Blood-Brain Barrier (BBB). FUS-BBBO is implicated in the treatment of several age-associated neuropathological disorders. The prevalence of these diseases in aged populations necessitates an investigation into and an understanding of the effect of age on the brain's response to FUS-BBBO. Here we show that advanced natural aging increases the brain's susceptibility to FUS-BBBO by increasing the volume of BBBO in response to equivalent sonication parameters. Additionally, the BBBO volume correlates positively with cavitation dose (CD). However, the extent of BBBO in response to cavitation is greater in two- compared to one-year old mice. Taken together, these results indicate an increased sensitivity in aged compared to younger mice, highlighting an important consideration in therapeutic planning.

引用

页数：3

共 11 条

[1]

[Anonymous], AGE DEPENDENT CHANGE

[2]

[Anonymous], CAVITATION MODULATED

[3]

[Anonymous], MODERN METHODS DELIV

[4] Alzheimer Disease in a Mouse Model: MR Imaging-guided Focused Ultrasound Targeted to the Hippocampus Opens the Blood-Brain Barrier and Improves Pathologic Abnormalities and Behavior [J].

Burgess, Alison ;

Dubey, Sonam ;

Yeung, Sharon ;

Hough, Olivia ;

Eterman, Naomi ;

Aubert, Isabelle ;

Hynynen, Kullervo .

RADIOLOGY, 2014, 273 (03) :736-745

[5] MOLECULES OF VARIOUS PHARMACOLOGICALLY-RELEVANT SIZES CAN CROSS THE ULTRASOUND-INDUCED BLOOD-BRAIN BARRIER OPENING IN VIVO [J].

Choi, James J. ;

Wang, Shougang ;

Tung, Yao-Sheng ;

Morrison, Barclay, III ;

Konofagou, Elisa E. .

ULTRASOUND IN MEDICINE AND BIOLOGY, 2010, 36 (01) :58-67

[6] The Blood-Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders [J].

Costea, Laura ;

Meszaros, Adam ;

Bauer, Hannelore ;

Bauer, Hans-Christian ;

Traweger, Andreas ;

Wilhelm, Imola ;

Farkas, Attila E. ;

Krizbai, Istvan A. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (21)

[7] Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound [J].

Hsu, Po-Hung ;

Wei, Kuo-Chen ;

Huang, Chiung-Yin ;

Wen, Chih-Jen ;

Yen, Tzu-Chen ;

Liu, Chao-Lin ;

Lin, Ya-Tin ;

Chen, Jin-Chung ;

Shen, Chia-Rui ;

Liu, Hao-Li .

PLOS ONE, 2013, 8 (02)

[8] Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model [J].

Karakatsani, Maria Eleni ;

Kugelman, Tara ;

Ji, Robin ;

Murillo, Maria ;

Wang, Shutao ;

Niimi, Yusuke ;

Small, Scott A. ;

Duff, Karen E. ;

Konofagou, Elisa E. .

THERANOSTICS, 2019, 9 (18) :5396-5411

[9]

Konofagou EE, 2012, CURR PHARM BIOTECHNO, V13, P1332

[10]

Pardridge William M, 2005, NeuroRx, V2, P3

← 1 2 →