Anti-tumor activity of heat-killed Lactobacillus plantarum BF-LP284 on Meth-A tumor cells in BALB/c mice

被引:22
作者
Shin, Ryoichi [1 ,2 ]
Itoh, Yukie [1 ]
Kataoka, Motoyuki [1 ]
Iino-Miura, Shiori [1 ]
Miura, Ryosuke [1 ]
Mizutani, Takeo [1 ]
Fujisawa, Tomohiko [2 ]
机构
[1] ALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
[2] Nippon Vet & Life Sci Univ, Sch Food Sci & Technol, Lab Food Hyg, Tokyo, Japan
关键词
Heat-killed; IFN-; Lactobacillus plantarum; probiotics; TNF-; tumor; SECONDARY LYMPHOID ORGANS; DENDRITIC CELLS; IMMUNE-RESPONSE; CANCER PREVENTION; BLADDER-CANCER; BEARING MICE; IN-VIVO; PROBIOTICS; MACROPHAGES; PRODUCTS;
D O I
10.1080/09637486.2016.1185771
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Probiotics exert numerous effects on human well-being. Here, heat-killed Lactobacillus plantarum BF-LP284 (H-Lp) was isolated as a potent immuno-modulator among 15 strains of lactobacilli in terms of TNF- induction ability in peritoneal macrophages. In vitro TNF- and IFN- induction in Peyer's patch (PP) cells was higher when incubated with H-Lp than with live L. plantarum BF-LP284 (L-Lp). Suppression of syngeneic Meth-A tumors in a murine model by oral administration of H-Lp was also greater than that of L-Lp and of controls. H-Lp stimulated IFN- production in spleen cells, which displayed inhibited tumor growth in Winn assays when treated with H-Lp. Moreover, H-Lp increased the ratio of CD3(+)cells among peripheral blood mononuclear cells in Meth-A tumor-bearing mice, suggesting an H-Lp-mediated anti-tumor mechanism whereby immune cells that are activated by H-Lp in PP and acquire anti-tumor activity in the spleen migrate to tumor sites through lymphocyte homing to inhibit tumor growth.
引用
收藏
页码:641 / 649
页数:9
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