Anti-tumor activity of heat-killed Lactobacillus plantarum BF-LP284 on Meth-A tumor cells in BALB/c mice
被引:22
作者:
Shin, Ryoichi
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ALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
Nippon Vet & Life Sci Univ, Sch Food Sci & Technol, Lab Food Hyg, Tokyo, JapanALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
Shin, Ryoichi
[1
,2
]
Itoh, Yukie
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ALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, JapanALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
Itoh, Yukie
[1
]
Kataoka, Motoyuki
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ALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, JapanALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
Kataoka, Motoyuki
[1
]
Iino-Miura, Shiori
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ALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, JapanALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
Iino-Miura, Shiori
[1
]
Miura, Ryosuke
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ALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, JapanALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
Miura, Ryosuke
[1
]
Mizutani, Takeo
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ALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, JapanALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
Mizutani, Takeo
[1
]
Fujisawa, Tomohiko
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Nippon Vet & Life Sci Univ, Sch Food Sci & Technol, Lab Food Hyg, Tokyo, JapanALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
Fujisawa, Tomohiko
[2
]
机构:
[1] ALA Corp, Cent Inst Hlth Sci, Tokyo 1750091, Japan
[2] Nippon Vet & Life Sci Univ, Sch Food Sci & Technol, Lab Food Hyg, Tokyo, Japan
Probiotics exert numerous effects on human well-being. Here, heat-killed Lactobacillus plantarum BF-LP284 (H-Lp) was isolated as a potent immuno-modulator among 15 strains of lactobacilli in terms of TNF- induction ability in peritoneal macrophages. In vitro TNF- and IFN- induction in Peyer's patch (PP) cells was higher when incubated with H-Lp than with live L. plantarum BF-LP284 (L-Lp). Suppression of syngeneic Meth-A tumors in a murine model by oral administration of H-Lp was also greater than that of L-Lp and of controls. H-Lp stimulated IFN- production in spleen cells, which displayed inhibited tumor growth in Winn assays when treated with H-Lp. Moreover, H-Lp increased the ratio of CD3(+)cells among peripheral blood mononuclear cells in Meth-A tumor-bearing mice, suggesting an H-Lp-mediated anti-tumor mechanism whereby immune cells that are activated by H-Lp in PP and acquire anti-tumor activity in the spleen migrate to tumor sites through lymphocyte homing to inhibit tumor growth.
机构:
Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, JapanNihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, Fujisawa, Kanagawa 2520880, Japan
Muto, Masamichi
;
Suyama, Akari
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机构:
Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, JapanNihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, Fujisawa, Kanagawa 2520880, Japan
Suyama, Akari
;
Hachimura, Satoshi
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机构:
Univ Tokyo, Res Ctr Food Safety, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, JapanNihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, Fujisawa, Kanagawa 2520880, Japan
Hachimura, Satoshi
;
Sato, Ryuichiro
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Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, JapanNihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, Fujisawa, Kanagawa 2520880, Japan
机构:
Univ Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5371, Australia
Children Youth & Womens Hlth Serv, Ctr Paediat & Adolescent Gastroenterol, Adelaide, SA 5006, AustraliaUniv Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5371, Australia
Howarth, Gordon S.
;
Wang, Hanru
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Univ Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5371, AustraliaUniv Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5371, Australia
机构:
Seoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South KoreaSeoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South Korea
Kim, Ji Yeun
;
Park, Myeong Soo
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机构:
Bifido Inc, Res Inst, Hongcheon 250804, Gangwondo, South KoreaSeoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South Korea
Park, Myeong Soo
;
Ji, Geun Eog
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机构:
Seoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South Korea
Bifido Inc, Res Inst, Hongcheon 250804, Gangwondo, South KoreaSeoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South Korea
机构:
Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, JapanNihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, Fujisawa, Kanagawa 2520880, Japan
Muto, Masamichi
;
Suyama, Akari
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, JapanNihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, Fujisawa, Kanagawa 2520880, Japan
Suyama, Akari
;
Hachimura, Satoshi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Res Ctr Food Safety, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, JapanNihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, Fujisawa, Kanagawa 2520880, Japan
Hachimura, Satoshi
;
Sato, Ryuichiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, JapanNihon Univ, Dept Food Biosci & Biotechnol, Coll Bioresource Sci, Fujisawa, Kanagawa 2520880, Japan
机构:
Univ Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5371, Australia
Children Youth & Womens Hlth Serv, Ctr Paediat & Adolescent Gastroenterol, Adelaide, SA 5006, AustraliaUniv Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5371, Australia
Howarth, Gordon S.
;
Wang, Hanru
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5371, AustraliaUniv Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5371, Australia
机构:
Seoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South KoreaSeoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South Korea
Kim, Ji Yeun
;
Park, Myeong Soo
论文数: 0引用数: 0
h-index: 0
机构:
Bifido Inc, Res Inst, Hongcheon 250804, Gangwondo, South KoreaSeoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South Korea
Park, Myeong Soo
;
Ji, Geun Eog
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South Korea
Bifido Inc, Res Inst, Hongcheon 250804, Gangwondo, South KoreaSeoul Natl Univ, Dept Food & Nutr, Res Inst Human Ecol, Coll Human Ecol, Seoul 152742, South Korea