Histone modifications and chromatin organization in prostate cancer

被引：50

作者：

Chen, Zhong ^{[1
,2
]}

Wang, Liguo ^{[3
]}

Wang, Qianben ^{[1
,2
]}

Li, Wei ^{[3
]}

机构：

[1] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA

[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[3] Baylor Coll Med, Houston, TX 77030 USA

来源：

EPIGENOMICS | 2010年 / 2卷 / 04期

关键词：

bioinformatics; CHIA-PET; ChIP-seq; chromatin organization; epigenome; Hi-C; histone modification; next-generation sequencing; prostate cancer; GROUP PROTEIN EZH2; ANDROGEN-RECEPTOR; DNA METHYLATION; HUMAN GENOME; GENE-EXPRESSION; TRANSCRIPT ELONGATION; T-CELLS; EPIGENETICS; POLYCOMB; CHROMOSOME;

D O I：

10.2217/EPI.10.31

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epigenetic mechanisms, including histone modifications, nucleosomal remodeling and chromosomal looping, contribute to the onset and progression of prostate cancer. Recent technical advances significantly increase our understanding of the genome-wide epigenetic regulation of gene expression in prostate cancer. Aberrant genomic distribution and global level of histone modifications, nucleosome repositioning at the gene promoter and enhancer regions, as well as androgen receptor-mediated chromosomal looping may lead to the silencing of tumor suppressor genes and the activation of proto-oncogenes. In addition, androgen receptor-induced chromosomal looping facilitates recurrent gene fusion in prostate cancer. Studies in epigenetic regulation have translational implications in the identification of new biomarkers and the development of new therapies in prostate cancer.

引用

页码：551 / 560

页数：10

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