Why is Wallerian degeneration in the CNS so slow?

被引：367

作者：

Vargas, Mauricio E. ^{[1
]}

Barres, Ben A. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2007年 / 30卷

关键词：

axotomy; myelin; phagocytosis; glia; macrophages;

D O I：

10.1146/annurev.neuro.30.051606.094354

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Wallerian degeneration (WD) is the set of molecular and cellular events by which degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the PNS but slow and incomplete in the CNS is a longstanding mystery Here we review current work on the mechanisms of WD with an emphasis on deciphering this mystery and on understanding whether slow WD in the CNS could account for the failure of CNS axons to regenerate.

引用

页码：153 / 179

页数：27

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