Medical and surgical perspectives of cardiac hypertrophy in Costello syndrome

被引:2
|
作者
Kalfa, David [1 ]
Fraisse, Alain [2 ]
Kreitmann, Bernard
机构
[1] Ctr Hosp Univ Marseille, Hop Enfants La Timone, Serv Chirurg Thorac & Cardiovasc, Dept Thorac & Cardiovasc Surg, F-13385 Marseille, France
[2] La Timone Childrens Hosp, Dept Paediat Cardiol, Marseille, France
关键词
Beta-blockers; hypertrophic cardiomyopathy; genetic syndrome; subaortic stenosis; supraventricular tachycardia; surgical myomectomy; DELINEATION; PHENOTYPE;
D O I
10.1017/S1047951109991181
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We describe our experience with 2 patients having Costello syndrome, aged 11 and 36 months, who suffered systolic anterior motion of the aortic leaflet of the mitral valve and obstructive cardiac hypertrophy requiring surgery, comparing their cardiac characteristics to those described previously. We conclude that the heterogeneous nature of the cardiac hypertrophy in this syndrome can be considered and managed as the sum of a diffuse hypertrophy accessible to beta-blockade, and an asymmetric hypertrophy accessible to surgical myomectomy.
引用
收藏
页码:644 / 647
页数:4
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