Solubility and thermodynamic properties of piperine in (acetone/ethyl acetate plus ethanol) at 278.15 K to 318.15 K and its correlation with the Jouyban-Acree and CNIBS/R-K models

被引：10

作者：

Wu, Yufang ^{[1
]}

Ma, Hui ^{[1
]}

Han, Yurui ^{[1
]}

机构：

[1] XinZhou Teachers Univ, Dept Biol Sci, Xinzhou 034000, Shanxi, Peoples R China

来源：

JOURNAL OF CHEMICAL THERMODYNAMICS | 2021年 / 161卷

关键词：

Piperine; Solubility; Cosolvent; Thermodynamic properties; BLACK PEPPER; PURE SOLVENTS; WATER; MIXTURES; METHANOL; ACID;

D O I：

10.1016/j.jct.2021.106555

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The effect of cosolvent on the dissolution process for piperine is an important aspect of its purification, recrystallization and clinical application. In this work, the solubility profile of piperine in acetone + ethanol and ethyl acetate + ethanol binary solvents with acetone / ethyl acetate mass fraction ranging from 0 to 1 at various temperatures ranging from 278.15 K to 318.15 K was measured and evaluated using JouybanAcree model and CNIBS/R-K model. The results showed that the solubility of piperine increased firstly and then decreased with the increasing mass fraction of acetone / ethyl acetate at a certain temperature. The solute-solvent interaction was analyzed by solubility parameters. The values of RAD show that the CNIBS/R-K model is more satisfactory to correlate the experimental data. Furthermore, apparent thermodynamic analysis indicate that the dissolution is an endothermic and entropy driven process. (c) 2021 Published by Elsevier Ltd.

引用

页数：7

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