Gene silencing - Methylation meets acetylation

被引：127

作者：

Bestor, TH ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

来源：

NATURE | 1998年 / 393卷 / 6683期

关键词：

D O I：

10.1038/30613

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Females have two copies of the X chromosome, yet the genes on only one copy are active. Genes on the other copy are turned off by cytosine methylation. For the first time, a link has been found between this methylation process and acetylation of histones —the protein balls around which the DNA in chromosomes is wrapped. A protein called MeCP2, which binds only to methylated DNA sequences, exists in a complex with histone deacetylase, which removes acetyl groups from the histones, causing them to condense and become transcriptionally inactive.

引用

页码：311 / 312

页数：2

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