Inclusion complexes of N-sulfamoyloxazolidinones with β-cyclodextrin

被引：14
作者：
Kadri, M
Djemil, R
Abdaoui, M
Winum, JY
Coutrot, F
Montero, JL
机构：
[1] Univ Guelma, Lab Chim Appl, Guelma 24000, Algeria
[2] Univ Montpellier 2, EMSCM, Lab Chim Biomol, UMR 5032, F-34296 Montpellier, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 04期
关键词：
N-sulfamoyoloxazolidinones; beta-cyclodextrin; inclusion complexes; second derivative spectrophotometry; ES-MS;
D O I：
10.1016/j.bmcl.2004.12.060
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A study of inclusion complexes of six N-sulfamoyloxazolidinone derivatives with beta-cyclodextrin is described. The inclusion complexes were prepared in solution and in solid state with stoichiometry host-guest 1:1, and characterized. In solution, the complexation was carried out by spectrophotometric measurements at 25 degreesC. The stoichiometries and stability constants of complexes at various pHs have been determined using second-derivative spectrophotometry UV-vis. Hydrophobic properties of N-sulfamoyloxazolidinones are improved following their inclusion into beta-CD. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：889 / 894
页数：6
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