The selective treatment of clinical mastitis based on on-farm culture results: I. Effects on antibiotic use, milk withholding time, and short-term clinical and bacteriological outcomes

被引:166
作者
Lago, A. [1 ]
Godden, S. M. [1 ]
Bey, R. [1 ]
Ruegg, P. L. [2 ]
Leslie, K. [3 ]
机构
[1] Univ Minnesota, Dept Vet Populat Med, Coll Vet Med, St Paul, MN 55108 USA
[2] Univ Wisconsin, Dept Dairy Sci, Coll Agr & Life Sci, Madison, WI 53706 USA
[3] Univ Guelph, Dept Populat Med, Ontario Vet Coll, Guelph, ON N1G 2W1, Canada
关键词
clinical mastitis; selective treatment; on-farm culture; bi-plate; ESCHERICHIA-COLI MASTITIS; ANTIMICROBIAL SUSCEPTIBILITY; DAIRY-COWS; ENVIRONMENTAL PATHOGENS; STAPHYLOCOCCUS-AUREUS; BOVINE MASTITIS; THERAPY; EFFICACY; PREVALENCE; RESISTANCE;
D O I
10.3168/jds.2010-4046
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
The objective of this multi-state, multi-herd clinical trial was to evaluate the efficacy of using an on-farm culture system to guide strategic treatment decisions in cows with clinical mastitis. The study was conducted in 8 commercial dairy farms ranging in size from 144 to 1,795 cows from Minnesota, Wisconsin, and Ontario, Canada. A total of 422 cows affected with mild or moderate clinical mastitis in 449 quarters were randomly assigned to either (1) a positive-control treatment program or (2) an on-farm, culture-based treatment program. Quarter cases assigned to the positive-control group received immediate on-label intramammary treatment with cephapirin sodium. Quarters assigned to the culture-based treatment program were cultured on-farm and treated with cephapirin sodium after 18 to 24 h of incubation if they had gram-positive growth or a mixed infection. Quarters with gram-negative or no growth did not receive intramammary therapy. The proportion of quarter cases assigned to positive-control and culture-based treatments that received intramammary antibiotic therapy because of study assignment was 100 and 44%, respectively; the proportion of cases that received secondary antibiotic therapy was 36 and 19%, respectively; and the proportion of cases that received intramammary antibiotic therapy because of study assignment or secondary therapy was 100 and 51%, respectively. A. tendency existed for a decrease in the number of days in which milk was discarded from cows assigned to the culture-based treatment program versus cows assigned to the positive-control group (5.9 vs. 5.2 d). No statistically significant differences existed between cases assigned to the positive-control and cases assigned to the culture-based treatment program in clays to clinical cure (2.7 vs. 3.2 d), bacteriological cure risk within 21 d of enrollment (71 vs. 60%), new intramammary infection risk within 21 d of enrollment (50 vs. 50%), and treatment failure risk (presence of infection, secondary treatment, clinical mastitis recurrence, or removal from herd within 21 d after enrollment; 81 vs. 78%). In summary, the use of an on-farm culture system to guide the strategic treatment of clinical mastitis reduced intramammary antibiotic use by half and tended to decrease milk withholding time by 1 d, without significant differences in days to clinical cure, bacteriological cure risk, new intramammary infection risk, and treatment failure risk within 21 d after the clinical mastitis event.
引用
收藏
页码:4441 / 4456
页数:16
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