Sleep Problems and Circadian Functioning in Children and Adolescents With Autism Spectrum Disorder

Background: Sleep problems are a prevalent comorbidity in autism spectrum disorder (ASD) with a multifactorial basis in which circadian misalignment has been described. Methods: A cross-sectional study was conducted including 52 children and adolescents with ASD (9.85 +/- 3.07) and 27 children and adolescent controls with normal intellectual functioning (8.81 +/- 2.14). They were matched for age, sex, and body mass index, and all were drug-naive. An ambulatory circadian monitoring device was used to record temperature and motor, body position, sleep, and light intensity. Results: Individuals with ASD presented longer sleep-onset latency, lower sleep efficiency, and decreased total sleep time and tended to be more sedentary and have less exposure to light. They also showed lower amplitude, low interdaily stability, and a different pattern of wrist temperature across the day, with a midpoint of sleep that did not concur with sleep midpoint indicated by the rest of circadian parameters. Conclusions: The sleep problems observed in this sample resemble those reported previously, with the exception of nocturnal awakenings which did not show differences. The ambulatory circadian monitoring device enabled measurement of circadian parameters such as temperature which, until now, were scarcely described in children with ASD and could be used to better understand sleep and circadian system in ASD. (c) 2021 Elsevier Inc. All rights reserved.