Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society

被引：9

作者：

Barboi, Alexandru ^{[1
,19
]}

Gibbons, Christopher H. ^{[2
]}

Axelrod, Felicia ^{[3
]}

Benarroch, Eduardo E. ^{[4
]}

Biaggioni, Italo ^{[5
]}

Chapleau, Mark W. ^{[6
,7
]}

Chelimsky, Gisela ^{[8
]}

Chelimsky, Thomas ^{[9
]}

Cheshire, William P. ^{[10
]}

Claydon, Victoria E. ^{[11
]}

Freeman, Roy ^{[2
]}

Goldstein, David S. ^{[12
]}

Joyner, Michael J. ^{[13
]}

Kaufmann, Horacio ^{[3
]}

Low, Phillip A. ^{[4
]}

Norcliffe-Kaufmann, Lucy ^{[14
,15
]}

Robertson, David ^{[5
]}

Shibao, Cyndya A. ^{[5
]}

Singer, Wolfgang ^{[4
]}

Snapper, Howard ^{[16
]}

Vernino, Steven ^{[17
]}

Raj, Satish R. ^{[5
,18
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Dept Neurol, NorthShore Univ Hlth Syst, Chicago, IL 60637 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[3] NYU, Dept Neurol, New York, NY 10016 USA

[4] Mayo Clin, Dept Neurol, Rochester, MN USA

[5] Vanderbilt Univ, Sch Med, Div Clin Pharmacol, Dept Med,Auton Dysfunct Ctr, Nashville, TN 37212 USA

[6] Univ Iowa, Dept Med, Iowa City, IA 52242 USA

[7] Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA USA

[8] Med Coll Wisconsin, Dept Pediat, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

[9] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA

[10] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[11] Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada

[12] NINDS, Auton Med Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[13] Mayo Clin, Dept Anesthesia & Perioperat Med, Rochester, MN USA

[14] NYU, Dept Physiol, New York, NY USA

[15] NYU, Dept Neurosci, New York, NY USA

[16] Wellstar Healthcare Syst, Div Cardiol, Atlanta, GA USA

[17] UT Southwestern Med Ctr, Dept Neurol & Neurotherapeut, Dallas, TX USA

[18] Univ Calgary, Dept Cardiac Sci, Libin Cardiovasc Inst Alberta, Calgary, AB, Canada

[19] Amer Auton Soc, 9500 Gilman Dr,BSB 5006, La Jolla, CA 92093 USA

来源：

CLINICAL AUTONOMIC RESEARCH | 2020年 / 30卷 / 01期

基金：

加拿大健康研究院;

关键词：

Consensus statement; Postural tachycardia syndrome; HPV; Vaccine; Autonomic dysfunction; ORTHOSTATIC TACHYCARDIA SYNDROME; AUTOIMMUNE-DISEASES; ADVERSE EVENTS; VIRUS; RISK; GIRLS; DYSAUTONOMIA; CANCER; SAFETY; INTOLERANCE;

D O I：

10.1007/s10286-019-00608-w

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Human papillomavirus (HPV) vaccination has been anecdotally connected to the development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome. Objectives To critically evaluate a potential connection between HPV vaccination and the above-noted conditions. Methods We reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders. Results At this time, the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, and postural tachycardia syndrome to other forms of dysautonomia. Conclusion Certain conditions are prevalent in the same populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is an insufficient proof of causality.

引用

页码：13 / 18

页数：6

共 56 条

[1] Human papillomavirus vaccine series completion in boys before and after recommendation for routine immunization [J].