Automated Raman Spectral Preprocessing of Bone and Other Musculoskeletal Tissues

被引：10

作者：

Esmonde-White, Francis W. L. ^{[1
]}

Schulmerich, Matthew V. ^{[1
,3
]}

Esmonde-White, Karen A. ^{[2
]}

Morris, Michael D. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, 930 N Univ, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[3] Univ Illinois, Urbana, IL 61801 USA

来源：

OPTICS IN BONE BIOLOGY AND DIAGNOSTICS | 2009年 / 7166卷

关键词：

Raman Spectroscopy; bone; musculoskeletal tissue; preprocessing; fluorescence removal; background correction; dichroic filter spectra; image rotation; spike removal; COSMIC-RAY HITS; FLUORESCENCE; ALGORITHM; REJECTION; REMOVAL;

D O I：

10.1117/12.809436

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Raman spectroscopy of bone is complicated by fluorescence background and spectral contributions from other tissues. Full utilization of Raman spectroscopy in bone studies requires rapid and accurate calibration and preprocessing methods. We have taken a step-wise approach to optimize and automate calibrations, preprocessing and background correction. Improvements to manual spike removal, white light correction, software image rotation and slit image curvature correction are described. Our approach is concisely described with a minimum of mathematical detail.

引用

页数：10

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