A facile tandem synthesis of α-benzyl benzimidazole acetonitriles

被引：11

作者：

Dubey, P. K. ^{[1
]}

Reddy, P. V. V. Prasada ^{[1
]}

Srinivas, K. ^{[1
]}

机构：

[1] Osmania Univ, Coll Engn, Dept Chem, Kukatpally, Hyderabad 500085, Andhra Pradesh, India

来源：

ARKIVOC | 2007年

关键词：

benzimidazoleacetonitriles; aromatic aldehydes; basic alumina; solvent-free; NaBH4;

D O I：

10.3998/ark.5550190.0008.f19

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient tandem method for the synthesis of alpha-benzylbenzimi dazoleacetonitriles has been developed. In this method, a benzimidazoleacetonitrile 1 was condensed with an aromatic aldehyde in the presence of basic alumina under solvent-free conditions by simple physical grinding of reactants using a mortar and pestle. Subsequent reduction of the in situ formed acrylonitrile derivative with NaBH4 in 95% ethanol at room temperature gives the corresponding 2-(1H-benzimidazol-2-yl)-3-aryl-propionitrile 3 by regiospecific reduction of the double bond.

引用

页码：192 / 198

页数：7

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