Efficacy of curcumin in the treatment of experimental vulvovaginal candidiasis

被引：11

作者：

Andrade, Jessica Tauany ^{[1
]}

de Figueiredo, Geisa Fantini ^{[2
]}

Cruz, Luisa Ferreira ^{[2
]}

de Morais, Sarah Eliza ^{[2
]}

Ferreira Souza, Carla Daiane ^{[1
]}

Horta Pinto, Flavia Carmo ^{[3
]}

Siqueira Ferreira, Jaqueline Maria ^{[1
]}

de Freitas Araujo, Marcelo Gonzaga ^{[2
]}

机构：

[1] Univ Fed Sao Joao del Rei, Lab Med Microbiol, Campus Ctr Oeste Dona Lindu, Divinopolis, MG, Brazil

[2] Univ Fed Sao Joao del Rei, Lab Pharmacol, Campus Ctr Oeste Dona Lindu, Divinopolis, MG, Brazil

[3] Univ Fed Sao Joao del Rei, Nat Sci Dept, Campus Dom Bosco, Sao Joao Del Rei, MG, Brazil

来源：

REVISTA IBEROAMERICANA DE MICOLOGIA | 2019年 / 36卷 / 04期

关键词：

Antifungal activity; Candida albicans; Curcumin; Ergosterol; Vulvovaginal candidiasis; ANTIFUNGAL ACTIVITY; DERIVATIVES; MECHANISM; ALBICANS; FUTURE; RISK;

D O I：

10.1016/j.riam.2019.01.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Candida albicans is the main agent that causes vulvovaginal candidiasis. Resistance among isolates to azole antifungal agents has been reported. Aims: Due to the well-known antifungal potential of curcumin, the purpose of this work was to evaluate the in vitro anticandidal activity of curcumin and its effect in the treatment of experimental vulvovaginal candidiasis. Methods: The anticandidal activity of curcumin was investigated against eight Candida strains by the broth microdilution assay, and its mechanism of action was evaluated by testing the binding to ergosterol. Then, the effect of curcumin in the treatment of vulvovaginal candidiasis was evaluated in an immunosuppressed, estrogen treated rat model. Results: Curcumin showed minimum inhibitory concentration values of 125-1000 mu g/ml, and the best result was observed against Candida glabrata. The compound was shown to be able to bind to the ergosterol present in the membrane, event that may be the mechanism of action. In addition, in the in vivo model of vulvovaginal candidiasis with C. albicans, treatments reduced the vaginal fungal burden in infected rats after seven days of treatment with different doses. Conclusions: Curcumin could be considered a promising effective antifungal agent in the treatment of vulvovaginal candidiasis. (C) 2019 Asociacion Espanola de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved.

引用

页码：192 / 199

页数：8

共 48 条

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