DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium

被引：14

作者：

Lozano, Manuel ^{[1
,2
]}

Yousefi, Paul ^{[3
,4
]}

Broberg, Karin ^{[5
,6
]}

Soler-Blasco, Raquel ^{[2
]}

Miyashita, Chihiro ^{[7
]}

Pesce, Giancarlo ^{[8
]}

Kim, Woo Jin ^{[9
,10
]}

Rahman, Mohammad ^{[11
,12
]}

Bakulski, Kelly M. ^{[13
]}

Haug, Line S. ^{[14
]}

Ikeda-Araki, Atsuko ^{[7
,15
]}

Huel, Guy ^{[8
]}

Park, Jaehyun ^{[16
]}

Relton, Caroline ^{[3
,4
]}

Vrijheid, Martine ^{[17
,18
,19
]}

Rifas-Shiman, Sheryl ^{[11
,12
]}

Oken, Emily ^{[11
,12
]}

Dou, John F. ^{[13
]}

Kishi, Reiko ^{[7
]}

Gutzkow, Kristine B. ^{[14
]}

Annesi-Maesano, Isabella ^{[20
]}

Won, Sungho ^{[16
,21
]}

Hivert, Marie-France ^{[11
,12
,22
]}

Fallin, M. Daniele ^{[23
]}

Vafeiadi, Marina ^{[24
]}

Ballester, Ferran ^{[2
,17
,25
]}

Bustamante, Mariona ^{[17
,18
,19
]}

Llop, Sabrina ^{[2
,17
]}

机构：

[1] Univ Valencia, Prevent Med & Publ Hlth, Food Sci Toxicol & Forens Med Dept, Av Vicent Andres Estelles S-N, Valencia 46100, Spain

[2] Univ Valencia, FISABIO Univ Jaume I, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain

[3] Univ Bristol, Integrat Epidemiol Unit, MRC, Bristol, Avon, England

[4] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England

[5] Karolinska Inst, Inst Environm Med, Unit Met & Hlth, Stockholm, Sweden

[6] Lund Univ, Div Occupat & Environm Med, Lund, Sweden

[7] Hokkaido Univ, Ctr Environm & Hlth Sci, Sapporo, Hokkaido, Japan

[8] Univ Paris Saclay, Ctr Epidemiol & Publ Hlth CESP, INSERM, UMR1018,UVSQ, Villejuif, France

[9] Kangwon Natl Univ, Dept Internal Med, Chunchon, South Korea

[10] Kangwon Natl Univ, Environm Hlth Ctr, Chunchon, South Korea

[11] Harvard Med Sch, Dept Populat Med, Div Chron Dis Res Lifecourse, Boston, MA 02115 USA

[12] Harvard Pilgrim Hlth Care Inst, Boston, MA 02115 USA

[13] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA

[14] Norwegian Inst Publ Hlth, Div Climate & Environm, Oslo, Norway

[15] Hokkaido Univ, Fac Hlth Sci, Sapporo, Hokkaido, Japan

[16] Seoul Natl Univ, Coll Nat Sci, Interdisciplinary Program Bioinformat, Seoul, South Korea

[17] Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain

[18] ISGIobal, Barcelona, Spain

[19] Univ Pompeu Fabra, Barcelona, Spain

[20] Montpellier Univ, Inst Desbrest Epidemiol & Sante Publ IDESP, INSERM, UMR1302, Montpellier, France

[21] Seoul Natl Univ, Dept Publ Hlth Sci, Seoul, South Korea

[22] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[23] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[24] Univ Crete, Sch Med, Dept Social Med, Iraklion, Greece

[25] Univ Valencia, Sch Nursing, Valencia, Spain

来源：

ENVIRONMENTAL RESEARCH | 2022年 / 204卷

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会; 英国医学研究理事会; 英国惠康基金; 日本学术振兴会; 欧盟地平线“2020”;

关键词：

DNA methylation; Mercury; Methylmercury; Prenatal exposure; PACE; HELIX study; ALSPAC; CORD BLOOD; SEAFOOD CONSUMPTION; OXIDATIVE STRESS; FETAL-GROWTH; CHILD COHORT; HUMAN HEALTH; R-PACKAGE; METHYLMERCURY; PROFILE; MOTHER;

D O I：

10.1016/j.envres.2021.112093

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (beta = 2.28 x 10-4, p-value = 5.87 x 10-5) in relation to prenatal MeHg exposure. In child blood, we identified

引用

页数：11

共 78 条

[1] Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes [J].