New once-daily formulation for trospium in overactive bladder

被引:10
作者
Chapple, C. [1 ]
机构
[1] Royal Hallamshire Hosp, Dept Urol, Sheffield S10 2JF, S Yorkshire, England
关键词
LIFE-STYLE FACTORS; COGNITIVE FUNCTION; EXTENDED-RELEASE; CHLORIDE; INCONTINENCE; EFFICACY; TOLERABILITY; ASSOCIATION; TOLTERODINE; PERSISTENCE;
D O I
10.1111/j.1742-1241.2010.02493.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
> Aims: We examined the relative efficacy and safety of trospium 20 mg bid and 60 mg extended release formulations and position this drug against other antimuscarinic agents. Methods: Data were identified on the pharmacology and pharmacokinetics of trospium chloride. Key publications on trospium 20-mg and 60-mg clinical studies in patients with overactive bladder (OAB) were identified and efficacy and safety compared between these formulations as well as other antimuscarinic agents. Results: Trospium offers the principal advantage over other antimuscarinic agents that, as it is a quaternary amine, it does not cross the blood-brain barrier and is therefore less likely to cause central nervous system effects observed with several other agents. Moreover, with its minimal liver metabolisation, independent of the main cytochrome pathways, trospium has a low risk of drug-drug interaction in patients taking multiple pharmacological agents. Trospium 60 mg ER is as effective as trospium 20 mg bid in improving the key outcome parameters associated with OAB, but with a lower rate of dry mouth, the most common side effect of these agents. Trospium has comparable efficacy and safety to the other antimuscarinic agents currently marketed. Discussion: Good patient persistence with treatment has been reported with trospium. There are currently a large number of antimuscarinic drugs on the market without clear evidence to distinguish one agent from another in terms of efficacy, provided that an adequate dose is used in the clinical setting. Conclusion: The new formulation of trospium is certainly worth considering as a pharmacological treatment of patients with OAB, particularly in the elderly, in whom one wants to avoid the potential for cognitive dysfunction.
引用
收藏
页码:1535 / 1540
页数:6
相关论文
共 32 条
[1]  
Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052
[2]   Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder [J].
Abrams, Paul ;
Andersson, Karl-Erik ;
Buccafusco, Jerry J. ;
Chapple, Christopher ;
de Groat, William Chet ;
Fryer, Alison D. ;
Kay, Gary ;
Laties, Alan ;
Nathanson, Neil M. ;
Pasricha, Pankaj Jay ;
Wein, Alan J. .
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 148 (05) :565-578
[3]   Persistence of antimuscarinic drug use [J].
Brostrom, Soren ;
Hallas, Jesper .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2009, 65 (03) :309-314
[4]   Efficacy of trospium chloride in patients with detrusor instability:: a placebo-controlled, randomized, double-blind, multicentre clinical trial [J].
Cardozo, L ;
Chapple, CR ;
Toozs-Hobson, P ;
Grosse-Freese, M ;
Bulitta, M ;
Lehmacher, W ;
Strösser, W ;
Ballering-Brühl, B ;
Schäfer, M .
BJU INTERNATIONAL, 2000, 85 (06) :659-664
[5]   The effects of antimuscarinic treatments in overactive bladder: An update of a systematic review and meta-analysis [J].
Chapple, Christopher R. ;
Khullar, Vik ;
Gabriel, Zahava ;
Muston, Dominic ;
Bitoun, Caty Ebel ;
Weinstein, David .
EUROPEAN UROLOGY, 2008, 54 (03) :543-562
[6]   The minor population of M3-receptors mediate contraction of human detrusor muscle in vitro [J].
Chess-Williams, R ;
Chapple, CR ;
Yamanishi, T ;
Yasuda, K ;
Sellers, DJ .
JOURNAL OF AUTONOMIC PHARMACOLOGY, 2001, 21 (5-6) :243-248
[7]   The association of diet and other lifestyle factors with the onset of overactive bladder: a longitudinal study in men [J].
Dallosso, HM ;
Matthews, RJ ;
McGrother, CW ;
Donaldson, MMK ;
Shaw, C .
PUBLIC HEALTH NUTRITION, 2004, 7 (07) :885-891
[8]   The association of diet and other lifestyle factors with overactive bladder and stress incontinence: a longitudinal study in women [J].
Dallosso, HM ;
McGrother, CW ;
Matthews, RJ ;
Donaldson, MMK .
BJU INTERNATIONAL, 2003, 92 (01) :69-77
[9]   Trospium 60 mg once daily (QD) for overactive bladder syndrome: Results from a placebo-controlled interventional study [J].
Dmochowski, Roger R. ;
Sand, Peter K. ;
Zinner, Norman R. ;
Staskin, David R. .
UROLOGY, 2008, 71 (03) :449-454
[10]   Long-term open-label solifenacin treatment associated with persistence with therapy in patients with overactive bladder syndrome [J].
Haab, F ;
Cardozo, L ;
Chapple, C ;
Ridder, AM .
EUROPEAN UROLOGY, 2005, 47 (03) :376-384