Nanocomposites Containing Gold Nanorods and Porphyrin-Doped Mesoporous Silica with Dual Capability of Two-Photon Imaging and Photosensitization

被引：99
作者：
Zhao, Tingting [1 ]
Wu, Hao [1 ]
Yao, Shao Q. [1 ]
Xu, Qing-Hua [1 ]
Xu, Guo Qin [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem, Fac Sci, Singapore 117543, Singapore
来源：
LANGMUIR | 2010年 / 26卷 / 18期
关键词：
PHOTODYNAMIC THERAPY; POLYMERIC MICELLES; GUEST MOLECULES; SINGLET OXYGEN; QUANTUM DOTS; IN-VIVO; NANOPARTICLES; FLUORESCENCE; CANCER; WATER;
D O I：
10.1021/la102556u
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel multifunctional nanoparticles that combine two functionalities (a gold nanorod core and a porphyrin-doped mesoporous silica shell) into one entity were synthesized Due to the encapsulation of mesoporous silica. the porphyrin can be well protected against the external bioenvironment In addition, the generated singlet oxygen by porphyrin molecules can be easily released from the silica. We have demonstrated that these multifunctional nanoparticles can generate singlet oxygen with relatively higher yield compared to free porphyrin These multifunctional nanocomposites are attractive candidates for simultaneous photosensitization and two-photon imaging as well as imaging guided therapy
引用
收藏
页码：14937 / 14942
页数：6
相关论文
共 39 条
  • [1] Design of organic molecules with large two-photon absorption cross sections
    Albota, M
    Beljonne, D
    Brédas, JL
    Ehrlich, JE
    Fu, JY
    Heikal, AA
    Hess, SE
    Kogej, T
    Levin, MD
    Marder, SR
    McCord-Maughon, D
    Perry, JW
    Röckel, H
    Rumi, M
    Subramaniam, C
    Webb, WW
    Wu, XL
    Xu, C
    [J]. SCIENCE, 1998, 281 (5383) : 1653 - 1656
  • [2] pH- and Photo-Switched Release of Guest Molecules from Mesoporous Silica Supports
    Aznar, Elena
    Dolores Marcos, Ma
    Martinez-Manez, Ramon
    Sancenon, Felix
    Soto, Juan
    Amoros, Pedro
    Guillem, Carmen
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (19) : 6833 - 6843
  • [3] PHOTODYNAMIC THERAPY FOR COLORECTAL-CANCER - A QUANTITATIVE PILOT-STUDY
    BARR, H
    KRASNER, N
    BOULOS, PB
    CHATLANI, P
    BOWN, SG
    [J]. BRITISH JOURNAL OF SURGERY, 1990, 77 (01) : 93 - 96
  • [4] Photodynamic therapy for cancer of the pancreas
    Bown, SG
    Rogowska, AZ
    Whitelaw, DE
    Lees, WR
    Lovat, LB
    Ripley, P
    Jones, L
    Wyld, P
    Gillams, A
    Hatfield, AWR
    [J]. GUT, 2002, 50 (04) : 549 - 557
  • [5] Fluorescence resonance energy transfer in novel multiphoton absorbing dendritic structures
    Brousmiche, DW
    Serin, JM
    Fréchet, JMJ
    He, GS
    Lin, TC
    Chung, SJ
    Prasad, PN
    Kannan, R
    Tan, LS
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (25) : 8592 - 8600
  • [6] Liposomes for photodynamic therapy
    Derycke, ASL
    de Witte, PAM
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (01) : 17 - 30
  • [7] Gold nanoparticles quench fluorescence by phase induced radiative rate suppression
    Dulkeith, E
    Ringler, M
    Klar, TA
    Feldmann, J
    Javier, AM
    Parak, WJ
    [J]. NANO LETTERS, 2005, 5 (04) : 585 - 589
  • [8] Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods
    Durr, Nicholas J.
    Larson, Timothy
    Smith, Danielle K.
    Korgel, Brian A.
    Sokolov, Konstantin
    Ben-Yakar, Adela
    [J]. NANO LETTERS, 2007, 7 (04) : 941 - 945
  • [9] Two-photon photosensitized production of singlet oxygen
    Frederiksen, PK
    Jorgensen, M
    Ogilby, PR
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (06) : 1215 - 1221
  • [10] Single-step coating of mesoporous silica on cetyltrimethyl ammonium bromide-capped nanoparticles
    Gorelikov, Ivan
    Matsuura, Naomi
    [J]. NANO LETTERS, 2008, 8 (01) : 369 - 373
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