Association between dysfunction of autonomic nervous system activity and mortality in schizophrenia

被引：11

作者：

Hattori, Saki ^{[1
]}

Suda, Akira ^{[1
]}

Kishida, Ikuko ^{[1
,2
]}

Miyauchi, Masatoshi ^{[1
]}

Shiraishi, Yohko ^{[1
]}

Fujibayashi, Mami ^{[3
]}

Tsujita, Natsuki ^{[4
]}

Ishii, Chie ^{[2
]}

Ishii, Norio ^{[2
]}

Moritani, Toshio ^{[5
]}

Saigusa, Yusuke ^{[6
]}

Hirayasu, Yoshio ^{[1
,7
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Psychiat, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan

[2] Fujisawa Hosp, 383 Kotuka, Fujisawa, Kanagawa 2518530, Japan

[3] Setsunan Univ, Div Phys & Hlth Educ, 17-8 Ikedanakamachi, Neyagawa, Osaka 5728508, Japan

[4] Kyoto Univ, Grad Sch Human & Environm Studies, Sakyo Ku, Yoshidanihonmatsucho, Kyoto 6068316, Japan

[5] Kyoto Sangyo Univ, Fac Gen Educ, Kita Ku, Kyoto 6068555, Japan

[6] Yokohama City Univ, Sch Med, Dept Biostat, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan

[7] Hirayasu Hosp, 346 Kyozuka, Urasoe, Okinawa 9012553, Japan

来源：

COMPREHENSIVE PSYCHIATRY | 2018年 / 86卷

基金：

日本学术振兴会;

关键词：

HEART-RATE-VARIABILITY; CARDIOVASCULAR-DISEASE; COHORT; RISK;

D O I：

10.1016/j.comppsych.2018.08.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Patients with schizophrenia have a higher mortality risk than the general population. Additionally, the autonomic nervous system (ANS) activity of patients with schizophrenia is lower and more dysfunctional than that of the general population. Nonetheless, the association between ANS dysfunction and mortality in schizophrenia is unclear. The aim of this study was to investigate the association between ANS activity and mortality in schizophrenia and to evaluate the predictive values of heart rate variability for long-term survival. Methods: This study involves the 10-year follow-up of a sample population consisting of 59 Japanese inpatients with schizophrenia between 60 and 70 years of age from 2007 to 2016. The ANS activity of all patients was evaluated using heart rate variability in 2007. Results: Fifty-three participants could be followed up because they stayed in the hospital during the follow-up period. Of these patients, 11 died during follow-up. Their mean age at death was 70.55 +/- 3.45 years. The parasympathetic activity of nonsurvivors was significantly lower than that of survivors, and multiple logistic regression analysis showed a significant association between death and parasympathetic activity. Conclusion: We suggest that decreased parasympathetic activity could be associated with 10-year all-cause mortality in older schizophrenic patients. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：119 / 122

页数：4

共 31 条

[21] Electrophysiology and kinesiology for health and disease [J].