Analysis and Determination of Anti-diabetes Drug Acarbose and its Structural Analogs

被引：17

作者：

Wang, Ya-Jun ^{[1
]}

Zheng, Yu-Guo ^{[1
]}

Xue, Ya-Ping ^{[1
]}

Wang, Yuan-Shan ^{[1
]}

Shen, Yin-Chu ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Inst Bioengn, Hangzhou 310032, Zhejiang, Peoples R China

来源：

CURRENT PHARMACEUTICAL ANALYSIS | 2011年 / 7卷 / 01期

关键词：

Diabetes; Acarbose; Analysis; Liquid chromatography; Capillary electrophoresis; Biosensor; GLUCOSIDASE INHIBITOR ACARBOSE; PERFORMANCE LIQUID-CHROMATOGRAPHY; LIGHT-SCATTERING DETECTOR; ACTINOPLANES SP CKD485-16; MODIFIED CARBON-BLACK; CAPILLARY-ELECTROPHORESIS; STENOTROPHOMONAS-MALTROPHILIA; CARDIOVASCULAR-DISEASE; MICROBIAL-DEGRADATION; SOLID CHROMATOGRAPHY;

D O I：

10.2174/157341211794708721

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acarbose is a clinically useful drug for the treatment of type II insulin-independent diabetes as a hypoglycemic agent. This minireview summarized detection and separation methods for the analysis and determination of anti-diabetes drug acarbose and its structural analogs, including HPLC, enzyme-based biosensor and capillary electrophoresis. Besides the protocol, principle behind each technique is presented together with its strengths and weaknesses. Finally, we analyze the future trends in the acarbose analysis.

引用

页码：12 / 20

页数：9

共 52 条

[1] Use of evaporative light scattering detection for the quality control of drug substances: Influence of different liquid chromatographic and evaporative light scattering detector parameters on the appearance of spike peaks [J].

Almeling, Stefan ;

Holzgrabe, Ulrike .

JOURNAL OF CHROMATOGRAPHY A, 2010, 1217 (14) :2163-2170

[2] Quantification of sugars and sugar phosphates in Arabidopsis thaliana tissues using porous graphitic carbon liquid chromatography-electrospray ionization mass spectrometry [J].

Antonio, Carla ;

Larson, Tony ;

Gilday, Alison ;

Graham, Ian ;

Bergstroem, Ed ;

Thomas-Oates, Jane .

JOURNAL OF CHROMATOGRAPHY A, 2007, 1172 (02) :170-178

[3] Electrochemical determination of carbohydrates: Enzyme electrodes and amperometric detection in liquid chromatography and capillary electrophoresis [J].

Baldwin, RP .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 19 (1-2) :69-81

[4]

BISCHOFF H, 1995, CLIN INVEST MED, V18, P303

[5] Biosynthetic studies on the α-glucosidase inhibitor acarbose:: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-α-D-glucose [J].

Bowers, SG ;

Mahmud, T ;

Floss, HG .

CARBOHYDRATE RESEARCH, 2002, 337 (04) :297-304

[6] Characterization of maltose and maltotriose transport in the acarbose-producing bacterium Actinoplanes sp. [J].

Brunkhorst, C ;

Schneider, E .

RESEARCH IN MICROBIOLOGY, 2005, 156 (08) :851-857

[7] Quantitative analysis of valienamine in the microbial degradation of validamycin A after derivatization with p-nitrofluorobenzene by reversed-phase high-performance liquid chromatography [J].

Chen, XL ;

Zheng, YG ;

Shen, YC .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 824 (1-2) :341-347

[8] A new method for production of valienamine with microbial degradation of acarbose [J].

Chen, XL ;

Zheng, YG ;

Shen, YC .

BIOTECHNOLOGY PROGRESS, 2005, 21 (03) :1002-1003

[9] Properties and production of valienamine and its related analogues [J].

Chen, XL ;

Fan, YX ;

Zheng, YU ;

Shen, YC .

CHEMICAL REVIEWS, 2003, 103 (05) :1955-1977

[10] Development and validation of liquid chromatography and capillary electrophoresis methods for acarbose determination in pharmaceutical tablets [J].

Cherkaoui, S ;

Daali, Y ;

Christen, P ;

Veuthey, JL .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1998, 18 (4-5) :729-735

← 1 2 3 4 5 6 →