Adult hippocampal neurogenesis in Alzheimer's disease

被引：21

作者：

Disouky, Ahmed ^{[1
]}

Lazarov, Orly ^{[1
]}

机构：

[1] Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USA

来源：

MOLECULAR BIOLOGY OF NEURODEGENERATIVE DISEASES: VISIONS FOR THE FUTURE, PT B | 2021年 / 177卷

关键词：

CELL-PROLIFERATION; PROGENITOR CELLS; DENTATE GYRUS; MOUSE MODEL; MICE; MEMORY; NEURONS; DISTINCT; ZONE;

D O I：

10.1016/bs.pmbts.2020.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New neurons are generated in the dentate gyrus of the adult brain throughout life. They incorporate in the granular cell layer of the dentate gyrus and integrate in the hippocampal circuitry. Increasing evidence suggests that new neurons play a role in learning and memory. In turn, a large body of evidence suggests that neurogenesis is impaired in Alzheimer's disease, contributing to memory deficits characterizing the disease. We outline here current knowledge about the biology of adult hippocampal neurogenesis and its function in learning and memory. In addition, we discuss evidence that neurogenesis is dysfunctional in Alzheimer's disease, address the controversy in the literature concerning the persistence of hippocampal neurogenesis in the adult and aging human brain, and evaluate the therapeutic potential of neurogenesis-based drug development for the treatment of cognitive deficits in Alzheimer's disease.

引用

页码：137 / 156

页数：20

共 74 条

[21] Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease [J].

Donovan, MH ;

Yazdani, U ;

Norris, RD ;

Games, D ;

German, DC ;

Eisch, AJ .

JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 495 (01) :70-83

[22] Spatial Relational Memory Requires Hippocampal Adult Neurogenesis [J].

Dupret, David ;

Revest, Jean-Michel ;

Koehl, Muriel ;

Ichas, Francois ;

De Giorgi, Francesca ;

Costet, Pierre ;

Abrous, Djoher Nora ;

Piazza, Pier Vincenzo .

PLOS ONE, 2008, 3 (04)

[23] Neurogenesis in the adult human hippocampus [J].

Eriksson, PS ;

Perfilieva, E ;

Björk-Eriksson, T ;

Alborn, AM ;

Nordborg, C ;

Peterson, DA ;

Gage, FH .

NATURE MEDICINE, 1998, 4 (11) :1313-1317

[24] Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis [J].

Ermini, Florian V. ;

Grathwohl, Stefan ;

Radde, Rebecca ;

Yamaguchi, Masohiro ;

Staufenbiel, Matthias ;

Palmer, Theo D. ;

Jucker, Mathias .

AMERICAN JOURNAL OF PATHOLOGY, 2008, 172 (06) :1520-1528

[25] Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease [J].

Faure, A. ;

Verret, L. ;

Bozon, B. ;

El Tayara, N. El Tannir ;

Ly, M. ;

Kober, F. ;

Dhenain, M. ;

Rampon, C. ;

Delatour, B. .

NEUROBIOLOGY OF AGING, 2011, 32 (03) :407-418

[26] Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces [J].

Feng, RB ;

Rampon, C ;

Tang, YP ;

Shrom, D ;

Jin, J ;

Kim, M ;

Sopher, B ;

Martin, GM ;

Kim, SH ;

Langdon, RB ;

Sisodia, SS ;

Tsien, JZ .

NEURON, 2001, 32 (05) :911-926

[27] Tau protein and adult hippocampal neurogenesis [J].

Fuster-Matanzo, Almudena ;

Llorens-Martin, Maria ;

Jurado-Arjona, Jeronimo ;

Avila, Jesus ;

Hernandez, Felix .

FRONTIERS IN NEUROSCIENCE, 2012, 6 :1-6

[28] Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer's disease-like transgenic (pPDGF-APPSW,Ind) mice [J].

Gan, Li ;

Qiao, Shuhong ;

Lan, Xun ;

Chi, Liying ;

Luo, Chun ;

Lien, Lindsey ;

Liu, Qing Yan ;

Liu, Rugao .

NEUROBIOLOGY OF DISEASE, 2008, 29 (01) :71-80

[29] Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies [J].

Garthe, Alexander ;

Behr, Joachim ;

Kempermann, Gerd .

PLOS ONE, 2009, 4 (05)

[30] YOUNG HIPPOCAMPAL NEURONS ARE CRITICAL FOR RECENT AND REMOTE SPATIAL MEMORY IN ADULT MICE [J].

Goodman, T. ;

Trouche, S. ;

Massou, I. ;

Verret, L. ;

Zerwas, M. ;

Roullet, P. ;

Rampon, C. .

NEUROSCIENCE, 2010, 171 (03) :769-778

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