Association of the long allele of the 5-httlpr polymorphism with compulsive craving in alcohol dependence

被引：43

作者：

Bleich, Stefan ^{[1
]}

Bönsch, Dominikus ^{[1
]}

Rauh, Johannes ^{[1
]}

Bayerlein, Kristina ^{[1
]}

Fiszer, Roland ^{[1
]}

Frieling, Helge ^{[1
]}

Hillemacher, Thomas ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Psychiat & psychotherapy, D-91054 Erlangen, Germany

来源：

ALCOHOL AND ALCOHOLISM | 2007年 / 42卷 / 06期

关键词：

D O I：

10.1093/alcalc/agm068

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Aims: Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism. Method: The present study investigated an association of this polymorphism with obsessive-compulsive alcohol craving in 124 male patients admitted for alcohol detoxification treatment. Results: We found significantly higher compulsive craving in patients with the long allele of the 5-HTTLPR polymorphism [at admission: analysis of variance (ANOVA): F=3.48, P=0.034, general linear model: F=3.92, P=0.023; after 7days: ANOVA: F=3.12, P=0.049]. Conclusions: Our results suggest that the long variant of the 5-HTTLPR polymorphism is associated with higher compulsive alcohol craving at the beginning of alcohol withdrawal.

引用

页码：509 / 512

页数：4

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