Suzuki arylation of 1,1-dibromo-1-alkenes: Synthesis of tetra-substituted alkenes

被引：37

作者：

Bauer, A ^{[1
]}

Miller, MW ^{[1
]}

Vice, SF ^{[1
]}

McCombie, SW ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Dept Chem Res, Kenilworth, NJ 07033 USA

来源：

SYNLETT | 2001年 / 02期

关键词：

Suzuki reaction; cross-coupling; arylations; palladium; alkenes;

D O I：

10.1055/s-2001-10776

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,1-Dibromo-1-alkenes were coupled with a variety of aryl boronic acids using Suzuki conditions (PdCl2(PPh3)(2)/Na2CO3/ THF-H2O or DME-H2O/65-90 degreesC). The 1,1-dibromo-1-alkenes were prepared from ketones, and thus, the overall process furnished tetra-substituted alkenes in a very efficient manner.

引用

页码：254 / 256

页数：3

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