FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

被引：2
作者：
Miroshnikova, Valentina V. [1 ,2 ]
Polyakova, Ekaterina A. [1 ]
Pobozheva, Irina A. [1 ,2 ]
Panteleeva, Aleksandra A. [1 ,2 ]
Razgildina, Natalia D. [2 ]
Kolodina, Diana A. [1 ]
Belyaeva, Olga D. [1 ]
Berkovich, Olga A. [1 ]
Pchelina, Sofya N. [1 ,2 ]
Baranova, Elena, I [1 ]
机构：
[1] Pavlov First St Petersburg State Med Univ, Lva Tolstogo Str 6-8 Bldg 28, St Petersburg 197022, Russia
[2] Natl Res Ctr, Petersburg Nucl Phys Inst, Kurchatov Inst, Gatchina, Russia
来源：
GENETICS AND MOLECULAR BIOLOGY | 2021年 / 44卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
Coronary artery disease; epicardial adipose tissue; subcutaneous adipose tissue; FABP4; omentin-1; BINDING PROTEIN 4; METABOLIC SYNDROME; SERUM OMENTIN-1; MACROPHAGES; FAT; ASSOCIATION; MEDIATORS; LEVEL;
D O I：
10.1590/1678-4685-GMB-2020-0441
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.
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页数：8
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