RATIOMETRIC FLUORESCENT-PROBE;
CHANGES IN-VIVO;
DRUG-RELEASE;
GEMCITABINE DELIVERY;
SELECTIVE DETECTION;
LIVING CELLS;
NAKED-EYE;
ON PROBE;
TURN-ON;
FLUOROPHORES;
D O I:
10.1021/acs.analchem.6b01135
中图分类号:
O65 [分析化学];
学科分类号:
070302 ;
081704 ;
摘要:
To reduce the side effects of chemotherapy, nontoxic prodrugs activated by the tumor microenvironrnent are urgently required for use in cancer treatment. In this work, we developed prodrug 4 for tumor-targeting treatment and imaging of the anticancer drug release in vivo. Taking advantage of the high glutathione (GSH) concentration in cancer cells, the disulfide bond in prodrug 4 was cleaved, resulting in the release of an active anticancer drug and a near-infrared (NIR) fluorescence dye turn-on. Furthermore, contrast to the free anticancer drug, the prodrug exhibited higher cytotoxicity to hepatoma cells than that to normal HL-7702 cells. Thus, prodrug 4 is a promising platform for specific tumor-activatable drug delivery system, because of its favorable features of in situ and in vivo monitoring of the drug release and therapeutic efficacy.
机构:
Univ Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Univ Rouen, CNRS, INSA Rouen, FR 3038, F-76821 Mont St Aignan, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Chevalier, Arnaud
;
Dubois, Martine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, PRES Normandy Univ, Lab Neuronal & Neuroendocrine Commun & Differenti, Inserm,Inst Res & Biomed Innovat IRIB,U982, F-76821 Mont St Aignan, France
North West Canceropole CNO, F-59008 Lille, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Dubois, Martine
;
Le Joncour, Vadim
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, PRES Normandy Univ, Lab Neuronal & Neuroendocrine Commun & Differenti, Inserm,Inst Res & Biomed Innovat IRIB,U982, F-76821 Mont St Aignan, France
North West Canceropole CNO, F-59008 Lille, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Le Joncour, Vadim
;
Dautrey, Sebastien
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Univ Rouen, CNRS, INSA Rouen, FR 3038, F-76821 Mont St Aignan, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Dautrey, Sebastien
;
Lecointre, Celine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, PRES Normandy Univ, Lab Neuronal & Neuroendocrine Commun & Differenti, Inserm,Inst Res & Biomed Innovat IRIB,U982, F-76821 Mont St Aignan, France
North West Canceropole CNO, F-59008 Lille, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Lecointre, Celine
;
论文数: 引用数:
h-index:
机构:
Romieu, Anthony
;
Renard, Pierre-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Univ Rouen, CNRS, INSA Rouen, FR 3038, F-76821 Mont St Aignan, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Renard, Pierre-Yves
;
Castel, Helene
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, PRES Normandy Univ, Lab Neuronal & Neuroendocrine Commun & Differenti, Inserm,Inst Res & Biomed Innovat IRIB,U982, F-76821 Mont St Aignan, France
North West Canceropole CNO, F-59008 Lille, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Castel, Helene
;
Sabot, Cyrille
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Univ Rouen, CNRS, INSA Rouen, FR 3038, F-76821 Mont St Aignan, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
机构:
Univ Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Univ Rouen, CNRS, INSA Rouen, FR 3038, F-76821 Mont St Aignan, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Chevalier, Arnaud
;
Dubois, Martine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, PRES Normandy Univ, Lab Neuronal & Neuroendocrine Commun & Differenti, Inserm,Inst Res & Biomed Innovat IRIB,U982, F-76821 Mont St Aignan, France
North West Canceropole CNO, F-59008 Lille, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Dubois, Martine
;
Le Joncour, Vadim
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, PRES Normandy Univ, Lab Neuronal & Neuroendocrine Commun & Differenti, Inserm,Inst Res & Biomed Innovat IRIB,U982, F-76821 Mont St Aignan, France
North West Canceropole CNO, F-59008 Lille, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Le Joncour, Vadim
;
Dautrey, Sebastien
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Univ Rouen, CNRS, INSA Rouen, FR 3038, F-76821 Mont St Aignan, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Dautrey, Sebastien
;
Lecointre, Celine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, PRES Normandy Univ, Lab Neuronal & Neuroendocrine Commun & Differenti, Inserm,Inst Res & Biomed Innovat IRIB,U982, F-76821 Mont St Aignan, France
North West Canceropole CNO, F-59008 Lille, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Lecointre, Celine
;
论文数: 引用数:
h-index:
机构:
Romieu, Anthony
;
Renard, Pierre-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Univ Rouen, CNRS, INSA Rouen, FR 3038, F-76821 Mont St Aignan, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Renard, Pierre-Yves
;
Castel, Helene
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, PRES Normandy Univ, Lab Neuronal & Neuroendocrine Commun & Differenti, Inserm,Inst Res & Biomed Innovat IRIB,U982, F-76821 Mont St Aignan, France
North West Canceropole CNO, F-59008 Lille, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Castel, Helene
;
Sabot, Cyrille
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France
Univ Rouen, CNRS, INSA Rouen, FR 3038, F-76821 Mont St Aignan, FranceUniv Rouen, Normandie Univ, UMR 6014, COBRA,INSA Rouen,CNRS, F-76821 Mont St Aignan, France