THE SYNTHESIS OF 5, 7-DIMETHYL-1, 2, 4-TRIAZOLO[1, 5A(14C)]PYRIMIDINE-2-CARBALDEHYDE FROM [14C]AMINOGUANIDINE: A KEY INTERMEDIATE FOR THE RADIOCHEMICAL GMP SYNTHESIS OF A DRUG CANDIDATE

被引：0
作者：
Rane, Anil M. [1 ]
Schildknegt, Klaas [1 ]
机构：
[1] Pfizer Global Res & Dev, Groton, CT 06340 USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2010年 / 53卷 / 5-6期
关键词：
Barium [C-14]cyanamide; S-methylisothio[C-14]urea; C-14]aminoguanidine bicarbonate; 5,7-Dimethyl-1,2,4-triazolo[1,5a(C-14)]pyrimidine-2-carbaldehyde; AMINOGUANIDINE; FORMS;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：257 / 260
页数：4
相关论文
共 7 条
[1]   SYNTHESES OF C-14 AND H-3 LABELED FORMS OF DONETIDINE - A HISTAMINE H-2-ANTAGONIST [J].
ARMITAGE, MA ;
CASHYAP, MM ;
SAUNDERS, D .
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1987, 24 (04) :431-445
[2]   Development of a synthetic process towards a hepatitis C polymerase inhibitor [J].
Camp, David ;
Matthews, Chris F. ;
Neville, Sean T. ;
Rouns, Michael ;
Scott, Robert W. ;
Truong, Yen .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2006, 10 (04) :814-821
[3]   SYNTHESES OF RADIOLABELED FORMS OF A NOVEL HISTAMINE H-1 ANTAGONIST (SK-AND-F 93944) [J].
CASHYAP, MM ;
MITCHELL, MB ;
OSBORNE, DC ;
SAUNDERS, D .
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1985, 22 (12) :1239-1250
[4]  
KURZER F, 1962, CHEM IND-LONDON, P1584
[5]   The chemistry of aminoguanidine and related substances [J].
Lieber, E ;
Smith, GBL .
CHEMICAL REVIEWS, 1939, 25 (02) :213-271
[6]   Synthesis of stable isotopically labelled versions of lamotrigine and its methylated metabolite [J].
Manning, CO ;
Wadsworth, AH ;
Fellows, I .
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2002, 45 (07) :611-618
[7]   Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells [J].
Plano, Daniel ;
Sanmartin, Carmen ;
Moreno, Esther ;
Prior, Celia ;
Calvo, Alfonso ;
Palop, Juan Antonio .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (24) :6853-6859
1