Linking SIRT2 to Parkinson's disease

被引：55

作者：

Garske, Adam L.

Smith, Brian C.

Denu, John M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

ACS CHEMICAL BIOLOGY | 2007年 / 2卷 / 08期

关键词：

D O I：

10.1021/cb700160d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent study has identified selective inhibitors of the human silent information regulator 2 NAD(+)-dependent protein deacetylase, SIRT2, and has shown that these compounds protect against alpha-synuctein-mediated toxicity in cellular models of Parkinson's disease. The inhibitors were found to ameliorate dopaminergic cell death in vitro and in a Drosophila model of Parkinson's disease. Although the molecular mechanism of action is unclear, the compounds may function by promoting the formation of enlarged inclusion bodies, which are suggested to provide a cell-survival advantage.

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页码：529 / 532

页数：4

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