Disinhibition in the Unaffected Hemisphere Is Related with the Cortical Involvement of the Affected Hemisphere

被引:4
作者
Oh, Byung-Mo [1 ,2 ]
Kim, Dae-Yul [1 ,3 ]
Paik, Nam-Jong [1 ]
机构
[1] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Rehabil Med, Songnam 463707, South Korea
[2] Seoul Natl Univ Hosp, Seoul 110744, South Korea
[3] Univ Ulsan, Coll Med, Asan Med Ctr, Seoul, South Korea
关键词
function; motor; motor-evoked potential (MEP); stroke; recovery; TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX DISINHIBITION; STROKE PATIENTS; POSTSTROKE REORGANIZATION; CONTROLLED TRIAL; FUNCTIONAL MRI; FOLLOW-UP; HAND; RECOVERY; BRAIN;
D O I
10.3109/00207451003760114
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To investigate whether the disinhibition of the unaffected hemisphere (UH) is related with the lesion location or integrity of the corticospinal tract, we evaluated the intracortical excitability of hand motor cortex in the UH using a paired-pulse transcranial magnetic stimulation paradigm short intracortical inhibition (sICI) and intracortical facilitation (ICF) in 30 subacute stroke survivors. The participants were then classified according to the lesion locations (cortical versus subcortical) and the presence of motor-evoked potential (MEP) response on the paretic hand (MEP+ versus MEP-). The sICI and ICF in the UH were compared according to lesion location and presence of paretic MEP. The sICI and ICF in the UH were comparable between MEP+ and MEP-groups. However, in terms of lesion location, intracortical inhibition was present in patients with subcortical lesions, whereas the patients with cortical lesions showed significant disinhibition in the UH. In conclusion, these findings support that the disinhibition of UH in subacute stage is related to the location of lesion rather than the integrity of the corticospinal tract.
引用
收藏
页码:512 / 515
页数:4
相关论文
共 25 条
  • [1] Hand function improvement with low-frequency repetitive transcranial magnetic stimulation of the unaffected hemisphere in a severe case of stroke
    Boggio, Paulo S.
    Alonso-Alonso, Miguel
    Mansur, Carlos G.
    Rigonatti, Sergio P.
    Schlaug, Gottfried
    Pascual-Leone, Alvaro
    Fregni, Felipe
    [J]. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 2006, 85 (11) : 927 - 930
  • [2] Remote changes in cortical excitability after stroke
    Bütefisch, CM
    Netz, J
    Wessling, M
    Seitz, RJ
    Hömberg, V
    [J]. BRAIN, 2003, 126 : 470 - 481
  • [3] Physiological studies of the corticomotor projection to the hand after subcortical stroke
    Byrnes, ML
    Thickbroom, GW
    Phillips, BA
    Wilson, SA
    Mastaglia, FL
    [J]. CLINICAL NEUROPHYSIOLOGY, 1999, 110 (03) : 487 - 498
  • [4] Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis
    Cao, Y
    D'Olhaberriague, L
    Vikingstad, EM
    Levine, SR
    Welch, KMA
    [J]. STROKE, 1998, 29 (01) : 112 - 122
  • [5] Interhemispheric asymmetries of motor cortex excitability in the postacute stroke stage - A paired-pulse transcranial magnetic stimulation study
    Cicinelli, P
    Pasqualetti, P
    Zaccagnini, M
    Traversa, R
    Oliveri, M
    Rossini, PM
    [J]. STROKE, 2003, 34 (11) : 2653 - 2658
  • [6] Post-stroke reorganization of brain motor output to the hand: a 2-4 month follow-up with focal magnetic transcranial stimulation
    Cicinelli, P
    Traversa, R
    Rossini, PM
    [J]. ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1997, 105 (06): : 438 - 450
  • [7] A functional MRI study of subjects recovered from hemiparetic stroke
    Cramer, SC
    Nelles, G
    Benson, RR
    Kaplan, JD
    Parker, RA
    Kwong, KK
    Kennedy, DN
    Finklestein, SP
    Rosen, BR
    [J]. STROKE, 1997, 28 (12) : 2518 - 2527
  • [8] Post-stroke reorganization of hand motor area:: a 1-year prospective follow-up with focal transcranial magnetic stimulation
    Delvaux, V
    Alagona, G
    Gérard, P
    De Pasqua, V
    Pennisi, G
    de Noordhout, AM
    [J]. CLINICAL NEUROPHYSIOLOGY, 2003, 114 (07) : 1217 - 1225
  • [9] Longitudinal study of motor recovery after stroke - Recruitment and focusing of brain activation
    Feydy, A
    Carlier, R
    Roby-Brami, A
    Bussel, B
    Cazalis, F
    Pierot, L
    Burnod, Y
    Maier, MA
    [J]. STROKE, 2002, 33 (06) : 1610 - 1617
  • [10] Transcranial direct current stimulation of the unaffected hemisphere in stroke patients
    Fregni, F
    Boggio, PS
    Mansur, CG
    Wagner, T
    Ferreira, MJL
    Lima, MC
    Rigonatti, SP
    Marcolin, MA
    Freedman, SD
    Nitsche, MA
    Pascual-Leone, A
    [J]. NEUROREPORT, 2005, 16 (14) : 1551 - 1555