Update on pathological platelet activation in coronary thrombosis

被引:35
作者
Elia, Edoardo [1 ]
Montecucco, Fabrizio [1 ,2 ,3 ]
Portincasa, Piero [4 ]
Sahebkar, Amirhossein [5 ,6 ,7 ]
Mollazadeh, Hamid [8 ]
Carbone, Federico [1 ]
机构
[1] Univ Genoa, Dept Internal Med, Clin Internal Med 1, Genoa, Italy
[2] Osped Policlin San Martino, Dept Internal Med, Clin Internal Med 1, 10 Largo Benzi, Genoa, Italy
[3] Univ Genoa, CEBR, Genoa, Italy
[4] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Bari, Italy
[5] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Dept Pharmaceut Biotechnol, Biotechnol Res Ctr, Mashhad, Iran
[6] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran
[7] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran
[8] North Khorasan Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Bojnurd, Iran
关键词
coronary thrombosis (CT); inflammasome; microvesicles (MVs); micro RNA (miRNA); neutrophil extracellular traps (NETs); platelet; stent thrombosis; DRUG-ELUTING STENTS; BARE-METAL STENTS; LOW-DENSITY-LIPOPROTEIN; NEUTROPHIL EXTRACELLULAR TRAPS; MYOCARDIAL-INFARCTION; ENDOTHELIAL-CELLS; CIRCULATING MICROPARTICLES; TISSUE FACTOR; RNA; REACTIVITY;
D O I
10.1002/jcp.27575
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Although coronary thrombosis (CT) is integral to cardiovascular outcomes, the underlying pathophysiological mechanisms remain unclear. CT may occur in case of atherosclerotic plaque erosion/rupture, or even after stenting implantation. Platelets (PLT) activation is the keystone of atherothrombosis and depends on many dysregulated elements, including endothelial dysfunction, oxidized lipoproteins, and immune response. Besides the classical view of PLT as an effector of hemostatic response, a new repertoire of PLT activities is emerging. PLT lipidome oxidation is a self-maintaining process which promotes PLT reactivity, coagulation cascade, and inflammatory cell activation. PLT-innate immune cell interaction is also sustained by neutrophil extracellular traps and NLRP3 inflammasome pathways. Other noteworthy emerging mechanisms are implicated in the crosstalk between PLT and surrounding cells. Especially, microvesicles (MVs) released from PLT may extend their signaling network far beyond the classical cell-cell interactions. Moreover, the recognition of noncoding RNA in PLT MVs introduce another layer of complexity in terms of intercellular signaling by a direct regulation of messenger RNA profile and gene expression in the recipient cells. The aim of this narrative review is to update the recent advance in CT and intracoronary stent thrombosis, including causal factors and potential translation of experimental evidence into the clinical setting.
引用
收藏
页码:2121 / 2133
页数:13
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