Transforming growth factor β: A potential biomarker and therapeutic target of ventricular remodeling

被引：45
作者：
Ma, Yuan [1 ,5 ]
Zou, Hai [1 ,5 ]
Zhu, Xing-Xing [2 ,5 ]
Pang, Jie [1 ,5 ]
Xu, Qiang [1 ,5 ]
Jin, Qin-Yang [1 ,5 ]
Ding, Ya-Hui [1 ,5 ]
Zhou, Bing [3 ,5 ]
Huang, Dong-Sheng [4 ,5 ]
机构：
[1] Zhejiang Prov Peoples Hosp, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Prov Peoples Hosp, Dept Cardiac Surg, Hangzhou, Zhejiang, Peoples R China
[4] Zhejiang Prov Peoples Hosp, Dept Hepatobiliary Surg, Hangzhou, Zhejiang, Peoples R China
[5] Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 32期
关键词：
transforming growth factor beta; myocardial fibrosis; ventricular remodeling; mechanism; targets; SPONTANEOUSLY HYPERTENSIVE-RATS; BETA/SMAD SIGNALING PATHWAY; REGULATES CARDIAC FIBROSIS; MYOCARDIAL-INFARCTION; PRESSURE-OVERLOAD; HEART-FAILURE; ENDOGLIN EXPRESSION; WNT/BETA-CATENIN; AORTIC-STENOSIS; SMAD PROTEINS;
D O I：
10.18632/oncotarget.17255
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transforming growth factor beta (TGF- beta) is a multifunctional cytokine that is synthesized by many types of cells and regulates the cell cycle. Increasing evidence has led to TGF-beta receiving increased and deserved attention in recent years because it may play a potentially novel and critical role in the development and progression of myocardial fibrosis and the subsequent progress of ventricular remodeling (VR). Numerous studies have highlighted a crucial role of TGF-beta in VR and suggest potential therapeutic targets of the TGF-beta signaling pathways for VR. Changes in TGF-beta activity may elicit anti-VR activity and may serve as a novel therapeutic target for VR therapy. This review we discusses the smad-dependent signaling pathway, such as TGF-beta/Smads, TGF-beta/Sirtuins, TGF-beta/BMP, TGF-beta/miRNAs, TGF-beta/MAPK, and Smad-independent signaling pathway of TGF-beta, such as TGF-beta/PI3K/Akt, TGF-beta/Rho/ROCK, TGF-beta/Wnt/beta-catenin in the cardiac fibrosis and subsequent progression of VR. Furthermore, agonists and antagonists of TGF-beta as potential therapeutic targets in VR are also described.
引用
收藏
页码：53780 / 53790
页数：11
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