The technology for improving stability of nanosuspensions in drug delivery

被引：23

作者：

Guan, Wenhao ^{[1
]}

Ma, Yingying ^{[1
]}

Ding, Shuaijie ^{[1
]}

Liu, Yanchao ^{[1
]}

Song, Zimin ^{[1
]}

Liu, Xiang ^{[1
]}

Tang, Lingling ^{[1
]}

Wang, Yancai ^{[1
]}

机构：

[1] Qilu Univ Technol, Sch Chem & Chem Engn, Shandong Acad Sci, Jinan 250353, Peoples R China

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2022年 / 24卷 / 01期

关键词：

Nanosuspensions; Stability; Solidification; Spray drying; Freeze-drying; IN-SITU GEL; SOLUTION-ENHANCED DISPERSION; SUPERCRITICAL FLUIDS SEDS; PARTICLE-SIZE REDUCTION; WATER-SOLUBLE DRUGS; GAS ANTISOLVENT GAS; MULTIFUNCTIONAL STABILIZER; PHYSICOCHEMICAL PROPERTIES; NANOCRYSTALS PRODUCTION; FORMULATION DEVELOPMENT;

D O I：

10.1007/s11051-022-05403-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review was devoted to the technology and approach for improving nanosuspensions stability in drug delivery to retrieve the state-of-the-art nanosuspensions. The main content of the present review included the nanosuspensions' preparation approach, methods and guidelines for selection and optimizing stabilizers, the approaches for enhancing stability, and the other influencing factors on the stability of the prepared nanosuspensions. For a given drug candidate having a set of properties, this review could be invoked as a reference in making an educated choice of stabilizer and improving the nanosuspensions' stability, rather than a trial-and-error approach that is being practiced currently.

引用

页数：38

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