Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer

被引:70
作者
Darshi, Manjula [1 ,2 ,3 ]
Van Espen, Benjamin [1 ,2 ]
Sharma, Kumar [1 ,2 ,3 ]
机构
[1] Univ Calif San Diego, Inst Metabol Med, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Ctr Renal Translat Med, La Jolla, CA 92093 USA
[3] Vet Affairs San Diego Healthcare Syst, Div Nephrol Hypertens, La Jolla, CA USA
关键词
Metabolomics; Diabetic kidney disease; Chronic kidney disease; GC-MS; Mitochondria; CHAIN FATTY-ACIDS; MASS-SPECTROMETRY; POTENTIAL BIOMARKERS; NMR-SPECTROSCOPY; KEY ROLE; PLASMA; REVEALS; URINE; SERUM; NEPHROPATHY;
D O I
10.1159/000447954
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The development of new therapies for chronic diseases, such as diabetic kidney disease (DKD), will continue to be hampered by lack of sufficient biomarkers that will provide insights and will be responsive to treatment interventions. The recent application of metabolomic technologies, such as nuclear magnetic resonance and mass spectroscopy, has allowed large-scale analysis of small molecules to be interrogated in a targeted or untargeted manner. Recent advances from both human and animal studies that have arisen from metabolomic analysis have recognized that mitochondria) function and fatty acid oxidation play key roles in the development and progression of DKD. Although many challenges in the technology for clinical chronic kidney disease (CKD) are yet to be validated, there will very likely be ongoing major contributions of metabolomics to develop new biochemical understanding for diabetic and CKD. The clinical application of metabolomics and accompanying bioinformatic tools will likely be a cornerstone of personalized medicine triumphs for CKD. (C) 2016 S. Karger AG, Basel
引用
收藏
页码:92 / 103
页数:12
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