How liquid biopsies can change clinical practice in oncology

被引：252

作者：

Siravegna, G. ^{[1
,2
]}

Mussolin, B. ^{[1
]}

Venesio, T. ^{[1
]}

Marsoni, S. ^{[3
]}

Seoane, J. ^{[4
,5
,6
]}

Dive, C. ^{[7
,8
]}

Papadopoulos, N. ^{[9
,10
]}

Kopetz, S. ^{[11
]}

Corcoran, R. B. ^{[12
,13
]}

Siu, L. L. ^{[14
]}

Bardelli, A. ^{[1
,2
]}

机构：

[1] IRCCS, FPO, Candiolo Canc Inst, Turin, Italy

[2] Univ Torino, Dept Oncol, SP 142 Km 3-95, I-10060 Turin, Italy

[3] IFOM, Milan, Italy

[4] Vall dHebron Univ Hosp, Vall dHebron Inst Oncol, Barcelona, Spain

[5] Univ Autonoma Barcelona, CIBERONC, Barcelona, Spain

[6] ICREA, Barcelona, Spain

[7] Univ Manchester, Canc Res UK Manchester Inst, Clin & Expt Pharmacol Grp, Manchester, Lancs, England

[8] Univ Manchester, Canc Res UK Manchester Inst, Manchester Ctr Canc Biomarker Sci, Manchester, Lancs, England

[9] Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD USA

[10] Johns Hopkins Univ, Sch Med, Sidney Kimmel Canc Ctr, Baltimore, MD USA

[11] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Div Canc Med, Houston, TX 77030 USA

[12] Harvard Med Sch, Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02115 USA

[13] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[14] Univ Toronto, Princess Margaret Canc Ctr, Toronto, ON, Canada

来源：

ANNALS OF ONCOLOGY | 2019年 / 30卷 / 10期

基金：

欧盟地平线“2020”;

关键词：

liquid biopsy; circulating free DNA; cancer diagnosis; resistance; minimal residual disease; clonal evolution; CIRCULATING TUMOR DNA; CELL-FREE-DNA; IMMUNE-RELATED RESPONSE; LUNG-CANCER; PLASMA DNA; BLOOD-PLASMA; INTRATUMOR HETEROGENEITY; NONINVASIVE DIAGNOSIS; ACQUIRED-RESISTANCE; NUCLEIC-ACIDS;

D O I：

10.1093/annonc/mdz227

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a variety of clinical applications. ctDNA is being used to genotype solid cancers non-invasively, to track tumor dynamics and to detect the emergence of drug resistance. In a few settings, liquid biopsies have already entered clinical practice. For example, ctDNA is used to guide treatment in a subset of lung cancers. In this review, we discuss how recent improvements in the sensitivity and accuracy of ctDNA analyses have led to unprecedented advances in this research field. We further consider what is required for the routine deployment of liquid biopsies in the clinical diagnostic space. We pinpoint technical hurdles that liquid biopsies have yet to overcome, including preanalytical and analytical challenges. We foresee how liquid biopsies will transform clinical practice: by complementing (or replacing) imaging to monitor treatment response and by detecting minimal residual disease after surgery with curative intent.

引用

页码：1580 / 1590

页数：11

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