Rhodium(III)-Catalyzed Meta-Selective C-H Alkenylation of Phenol Derivatives

被引：39

作者：

Mi, Rui-Jie ^{[1
]}

Sun, Yong-Zhen ^{[1
]}

Wang, Jing-Yun ^{[1
]}

Sun, Jing ^{[1
]}

Xu, Zhaoqing ^{[2
]}

Zhou, Ming-Dong ^{[1
]}

机构：

[1] Liaoning Shihua Univ, Sch Chem & Mat Sci, Fushun 113001, Peoples R China

[2] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 17期

关键词：

BOND FUNCTIONALIZATION; DIRECTING GROUP; N BOND; CYCLATIVE CAPTURE; COUPLING REACTION; ACTIVATION; OLEFINATION; TEMPLATE; ARENES; ARYLATION;

D O I：

10.1021/acs.orglett.8b01995

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium(III)-catalyzed remote meta-selective C-H alkenylation of phenol derivatives has been developed using a traceless organosilicon template as the directing group. This transformation proceeds smoothly with good yields and high meta-selectivities toward a series of phenol and alkene substrates. In addition, this protocol provides an effective strategy for late-stage transformations of various meta-alkenylated aromatic compounds.

引用

页码：5126 / 5129

页数：4

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