Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin

被引：2

作者：

Yamane, Takumi ^{[1
]}

Kitaura, Yasuyuki ^{[2
]}

Iwatsuki, Ken ^{[1
]}

Shimomura, Yoshiharu ^{[3
]}

Oishi, Yuichi ^{[1
]}

机构：

[1] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutr Sci & Food Safety, Setagaya Ku, Tokyo, Japan

[2] Nagoya Univ, Grad Sch Bioagr Sci, Lab Nutr Biochem, Nagoya, Aichi, Japan

[3] Chubu Univ, Coll Biosci & Biotechnol, Dept Food & Nutr Sci, Kasugai, Aichi, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2021年 / 85卷 / 11期

关键词：

branched-chain amino acid; hyaluronan; hyaluronan synthase; skin; PROTEIN;

D O I：

10.1093/bbb/zbab160

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effects of deletion of branched-chain alpha-keto acid dehydrogenase kinase (BDK), a key enzyme in branched-chain amino acid catabolism, on hyaluronan synthesis in mice. The skin levels of hyaluronan and the gene expression levels of hyaluronan synthase (Has)2, Has3, and peroxisome proliferator-activated receptor-alpha were significantly lower in the BDK-knockout group than in the wild-type group.

引用

页码：2292 / 2294

页数：3

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