Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin

被引：2
|
作者：
Yamane, Takumi [1 ]
Kitaura, Yasuyuki [2 ]
Iwatsuki, Ken [1 ]
Shimomura, Yoshiharu [3 ]
Oishi, Yuichi [1 ]
机构：
[1] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutr Sci & Food Safety, Setagaya Ku, Tokyo, Japan
[2] Nagoya Univ, Grad Sch Bioagr Sci, Lab Nutr Biochem, Nagoya, Aichi, Japan
[3] Chubu Univ, Coll Biosci & Biotechnol, Dept Food & Nutr Sci, Kasugai, Aichi, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2021年 / 85卷 / 11期
关键词：
branched-chain amino acid; hyaluronan; hyaluronan synthase; skin; PROTEIN;
D O I：
10.1093/bbb/zbab160
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We examined the effects of deletion of branched-chain alpha-keto acid dehydrogenase kinase (BDK), a key enzyme in branched-chain amino acid catabolism, on hyaluronan synthesis in mice. The skin levels of hyaluronan and the gene expression levels of hyaluronan synthase (Has)2, Has3, and peroxisome proliferator-activated receptor-alpha were significantly lower in the BDK-knockout group than in the wild-type group.
引用
收藏
页码：2292 / 2294
页数：3
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