Lipin Family Proteins - Key Regulators in Lipid Metabolism

被引：65

作者：

Chen, Yi ^{[1
]}

Rui, Bei-Bei ^{[2
]}

Tang, Li-Ying ^{[1
]}

Hu, Cheng-Mu ^{[1
]}

机构：

[1] Anhui Med Univ, Sch Pharm, Anhui Key Lab Bioact Nat Prod, Hefei 230032, Peoples R China

[2] Anhui Med Univ, Inst Clin Pharmacol, Key Lab Antiinflamnnatory & Imnnunopharmacol, Educ Minist, Hefei 230032, Peoples R China

来源：

ANNALS OF NUTRITION AND METABOLISM | 2015年 / 66卷 / 01期

关键词：

Lipin; Obesity; Lipodystrophy; Phosphatidate phosphatase; Transcriptional coactivator; ACTIVATED-RECEPTOR-GAMMA; PHOSPHATIDATE PHOSPHOHYDROLASE; ADIPOSE-TISSUE; SUBCELLULAR-LOCALIZATION; HEPATIC LIPIN-1; GENE-EXPRESSION; FATTY LIVER; PHOSPHORYLATION; LIPODYSTROPHY; MOUSE;

D O I：

10.1159/000368661

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Proteins in the lipin family play a key role in lipid synthesis due to their phosphatidate phosphatase activity, and they also act as transcriptional coactivators to regulate the expression of genes involved in lipid metabolism. The lipin family includes three members, lipin1, lipin2, and lipin3, which exhibit tissue-specific expression, indicating that they may have distinct roles in mediating disease. To date, most studies have focused on lipin1, whereas the roles of lipin2 and lipin3 are less understood. Summary: This review introduces the structural characteristics, physiological functions, relationship to lipid metabolism, and patterns of expression of the lipin family proteins, highlighting their roles in lipid metabolic homeostasis. (C) 2014 S. Karger AG, Basel

引用

页码：10 / 18

页数：9

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