Lipin Family Proteins - Key Regulators in Lipid Metabolism

被引：66

作者：

Chen, Yi ^{[1
]}

Rui, Bei-Bei ^{[2
]}

Tang, Li-Ying ^{[1
]}

Hu, Cheng-Mu ^{[1
]}

机构：

[1] Anhui Med Univ, Sch Pharm, Anhui Key Lab Bioact Nat Prod, Hefei 230032, Peoples R China

[2] Anhui Med Univ, Inst Clin Pharmacol, Key Lab Antiinflamnnatory & Imnnunopharmacol, Educ Minist, Hefei 230032, Peoples R China

来源：

ANNALS OF NUTRITION AND METABOLISM | 2015年 / 66卷 / 01期

关键词：

Lipin; Obesity; Lipodystrophy; Phosphatidate phosphatase; Transcriptional coactivator; ACTIVATED-RECEPTOR-GAMMA; PHOSPHATIDATE PHOSPHOHYDROLASE; ADIPOSE-TISSUE; SUBCELLULAR-LOCALIZATION; HEPATIC LIPIN-1; GENE-EXPRESSION; FATTY LIVER; PHOSPHORYLATION; LIPODYSTROPHY; MOUSE;

D O I：

10.1159/000368661

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Proteins in the lipin family play a key role in lipid synthesis due to their phosphatidate phosphatase activity, and they also act as transcriptional coactivators to regulate the expression of genes involved in lipid metabolism. The lipin family includes three members, lipin1, lipin2, and lipin3, which exhibit tissue-specific expression, indicating that they may have distinct roles in mediating disease. To date, most studies have focused on lipin1, whereas the roles of lipin2 and lipin3 are less understood. Summary: This review introduces the structural characteristics, physiological functions, relationship to lipid metabolism, and patterns of expression of the lipin family proteins, highlighting their roles in lipid metabolic homeostasis. (C) 2014 S. Karger AG, Basel

引用

页码：10 / 18

页数：9

共 50 条

[1] The Role of Lipin Proteins in Lipid Storage and Metabolism
Reue, Karen
FASEB JOURNAL, 2009, 23
[2] Lipin 1 in Lipid Metabolism
Ishimoto, Kenji
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2011, 131 (08): : 1189 - 1194
[3] The lipin family: mutations and metabolism
Reue, Karen
CURRENT OPINION IN LIPIDOLOGY, 2009, 20 (03) : 165 - 170
[4] The CREB Family: key regulators of hepatic metabolism
Montminy, M
Koo, SH
Zhang, X
ANNALES D ENDOCRINOLOGIE, 2004, 65 (01) : 73 - 75
[5] Cellular lipid binding proteins as facilitators and regulators of lipid metabolism
Glatz, JFC
Luiken, JJFP
van Bilsen, M
van der Vusse, GJ
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 239 (1-2) : 3 - 7
[6] Cellular lipid binding proteins as facilitators and regulators of lipid metabolism
Jan F.C. Glatz
Joost J.F.P. Luiken
Marc van Bilsen
Ger J. van der Vusse
Molecular and Cellular Biochemistry, 2002, 239 : 3 - 7
[7] Dual function lipin proteins and glycerolipid metabolism
Harris, Thurl E.
Finck, Brian N.
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2011, 22 (06): : 226 - 233
[8] BCL-2 family proteins as regulators of mitochondria metabolism
Gross, Atan
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2016, 1857 (08): : 1243 - 1246
[9] The Lipin Protein Family, Cellular Lipid Storage, and Disease
Reue, Karen
FASEB JOURNAL, 2015, 29
[10] BCL-2 Family Proteins: The Mitochondrial Apoptotic Key Regulators
Daisy, P.
Saipriya, K.
CURRENT CANCER THERAPY REVIEWS, 2012, 8 (02) : 133 - 140

← 1 2 3 4 5 →