Current understanding and importance of histone phosphorylation in regulating chromatin biology

被引：0

作者：

Perez-Cadahia, Beatriz ^{[2
]}

Drobic, Bojan ^{[1
]}

Khan, Protiti ^{[1
]}

Shivashankar, Chaitra C. ^{[1
]}

Davie, James R. ^{[1
]}

机构：

[1] Univ Manitoba, Manitoba Inst Cell Biol, Winnipeg, MB R3E 0V9, Canada

[2] Univ A Coruna, Toxicol Unit, Dept Psychobiol, La Coruna 15071, Spain

来源：

CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2010年 / 13卷 / 05期

关键词：

Apoptosis; chromatin; chromatin structure; chromatin function; DNA repair; histone phosphorylation; mitosis; transcription; DOUBLE-STRAND BREAKS; MITOSIS-SPECIFIC PHOSPHORYLATION; MITOTIC CHROMOSOME CONDENSATION; INACTIVE X-CHROMOSOME; DNA-DAMAGE RESPONSE; POSTTRANSLATIONAL MODIFICATIONS; DEPHOSPHORYLATES GAMMA-H2AX; H3; PHOSPHORYLATION; MASS-SPECTROMETRY; SERINE-1;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The core histones H2A, H2B, H3 and H4, undergo various post-translational modifications, such as acetylation, methylation and phosphorylation. Core histone phosphorylation has roles in several biological responses, including transcription, mitosis, DNA repair and apoptosis. Histone phosphorylation may disrupt chromatin structure and/or provide a 'code' for the recruitment or occlusion of non-histone chromosomal proteins to chromatin. Among the better-characterized histone phosphorylation events are the phosphorylation of H3 at Ser(10) and Ser(28), and the phosphorylation of the H2A variant H2A. X at Ser(139). Much remains to be learned about the function of the many other core histone phosphorylation events in chromatin. This review provides an overview of the biological roles of core histone phosphorylation in mammalian cells.

引用

页码：613 / 622

页数：10

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