Copper-Catalyzed Aerobic Oxidative Regioselective Thiocyanation of Aromatics and Heteroaromatics

被引：106

作者：

Jiang, Huanfeng ^{[1
]}

Yu, Wentao ^{[1
]}

Tang, Xiaodong ^{[1
]}

Li, Jianxiao ^{[1
]}

Wu, Wanqing ^{[1
]}

机构：

[1] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 18期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; BOND FUNCTIONALIZATION; DIFLUOROMETHYL THIOETHERS; AMMONIUM THIOCYANATE; EFFICIENT SYNTHESIS; VERSATILE REAGENT; FACILE SYNTHESIS; MILD CONDITIONS; ARENES; CHEMISTRY;

D O I：

10.1021/acs.joc.7b01122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed aerobic oxidative reaction between aromatics or heteroaromatics with KSCN is developed by using O-2 as the oxidant. The combination of Cu(OTf)(2), N,N,N',N'-tetramethylethylenediamine (TMEDA) and BF3 center dot Et2O provides an efficient catalytic system, affording substituted thiocyanation products and 2-aminobenzothiazoles in excellent yields. The reaction also possesses a good functional group tolerance for both strong electron-withdrawing and electron-donating groups.

引用

页码：9312 / 9320

页数：9

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