Synthesis, Structure, and Antiradical Activity of New Methano[1,3]Thiazolo[2,3-d][1,3,5]Benzoxa-Diazocine Derivatives

被引：12
|
作者：
Kulakov, I. V. [1 ]
Talipov, S. A. [2 ]
Shulgau, Z. T. [3 ]
Seilkhanov, T. M. [4 ]
机构：
[1] Omsk FM Dostoevskii State Univ, Omsk 644077, Russia
[2] Inst Bioorgan Chem, Tashkent 100125, Uzbekistan
[3] Ctr Life Sci Inc, Astana 010000, Kazakhstan
[4] Sh Ualikhanov Kokshetau State Univ, Kokshetau 020000, Kazakhstan
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 50卷 / 10期
关键词：
2H-2,6-methano[1,3,5]benzoxadiazocines; salicylic aldehyde; thiourea; Biginelli reaction; intramolecular heterocyclization; X-ray structural analysis; ONE-POT SYNTHESIS; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; MICROWAVE IRRADIATION; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CONDENSATION; EFFICIENT; CHEMISTRY;
D O I：
10.1007/s10593-014-1613-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 2,6-methano[1, 3, 5]benzoxadiazocines, obtained in Biginelli reaction, with chloroacetic acid derivatives produced previously unknown tricyclic methano[1,3]thiazolo[2,3-d][1,3,5]benz-oxadiazocines, the structure of which was proved by (1)De NMR spectroscopy and X-ray structural analysis. The methano[1,3]thiazolo[2,3-d][1,3,5]benzoxadiazocines showed no antiradical activity in contrast to the starting 2,6-methano[1,3,5]benzoxadiazocines.
引用
收藏
页码：1478 / 1486
页数：9
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