Synthesis, Structure, and Antiradical Activity of New Methano[1,3]Thiazolo[2,3-d][1,3,5]Benzoxa-Diazocine Derivatives

被引：12

作者：

Kulakov, I. V. ^{[1
]}

Talipov, S. A. ^{[2
]}

Shulgau, Z. T. ^{[3
]}

Seilkhanov, T. M. ^{[4
]}

机构：

[1] Omsk FM Dostoevskii State Univ, Omsk 644077, Russia

[2] Inst Bioorgan Chem, Tashkent 100125, Uzbekistan

[3] Ctr Life Sci Inc, Astana 010000, Kazakhstan

[4] Sh Ualikhanov Kokshetau State Univ, Kokshetau 020000, Kazakhstan

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 50卷 / 10期

关键词：

2H-2,6-methano[1,3,5]benzoxadiazocines; salicylic aldehyde; thiourea; Biginelli reaction; intramolecular heterocyclization; X-ray structural analysis; ONE-POT SYNTHESIS; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; MICROWAVE IRRADIATION; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CONDENSATION; EFFICIENT; CHEMISTRY;

D O I：

10.1007/s10593-014-1613-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 2,6-methano[1, 3, 5]benzoxadiazocines, obtained in Biginelli reaction, with chloroacetic acid derivatives produced previously unknown tricyclic methano[1,3]thiazolo[2,3-d][1,3,5]benz-oxadiazocines, the structure of which was proved by (1)De NMR spectroscopy and X-ray structural analysis. The methano[1,3]thiazolo[2,3-d][1,3,5]benzoxadiazocines showed no antiradical activity in contrast to the starting 2,6-methano[1,3,5]benzoxadiazocines.

引用

页码：1478 / 1486

页数：9

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