Posaconazole Treatment of Extensive Skin and Nail Dermatophytosis Due to Autosomal Recessive Deficiency of CARD9

被引：56

作者：

Jachiet, Marie ^{[1
]}

Lanternier, Fanny ^{[2
,3
]}

Rybojad, Michel ^{[1
]}

Bagot, Martine ^{[1
]}

Ibrahim, Lina ^{[1
]}

Casanova, Jean-Laurent ^{[2
]}

Puel, Anne ^{[2
]}

Bouaziz, Jean-David ^{[1
]}

机构：

[1] Univ Paris 07, Hop St Louis, AP HP, Sorbonne Paris Cite,Dept Dermatol, F-75475 Paris, France

[2] Paris Descartes Univ, Imagine Inst, Lab Human Genet Infect Dis, Sorbonne Paris Cite,Necker Branch, Paris, France

[3] Paris Descartes Univ, Imagine Inst, Infect Dis Unit, Necker Enfants Malad Hosp, Paris, France

来源：

JAMA DERMATOLOGY | 2015年 / 151卷 / 02期

关键词：

FUNGAL-INFECTIONS; DISEASE;

D O I：

10.1001/jamadermatol.2014.2154

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

IMPORTANCE Deep dermatophytosis is a disease that involves dermatophytic infection of the dermis and/or lymph nodes and sometimes the central nervous system. Autosomal recessive deficiency of the CARD9 (caspase recruitment domain 9) protein has been described in 17 patients with deep dermatophytosis from Algeria, Tunisia, and Morocco. OBSERVATIONS We report a case of extensive dermatophytosis due to autosomal recessive CARD9 deficiency in a patient of Egyptian origin. This patient had extensive superficial Trichophyton rubrum infection of the skin and nails without significant visceral involvement. Treatment with posaconazole was well tolerated and induced a complete clinical remission within 3 months that continued for 8 months of follow-up. CONCLUSIONS AND RELEVANCE This case report underlines the phenotypic variability of dermatophytic infection in patients with CARD9 deficiency and the potential efficacy of posaconazole for this indication.

引用

页码：192 / 194

页数：3

共 15 条

[1] In vitro activity of posaconazole against clinical isolates of dermatophytes [J].

Barchiesi, F ;

Arzeni, D ;

Camiletti, V ;

Simonetti, O ;

Cellini, A ;

Offidani, AM ;

Scalise, G .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (11) :4208-4209

[2] A fatal case of dermatophytic disease with retropharyngeal abscess [J].

Cheikhrouhou, F. ;

Makni, F. ;

Masmoudi, A. ;

Sellami, A. ;

Turki, H. ;

Ayadi, A. .

ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2010, 137 (03) :208-211

[3] Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group [J].

De Pauw, Ben ;

Walsh, Thomas J. ;

Donnelly, J. Peter ;

Stevens, David A. ;

Edwards, John E. ;

Calandra, Thierry ;

Pappas, Peter G. ;

Maertens, Johan ;

Lortholary, Olivier ;

Kauffman, Carol A. ;

Denning, David W. ;

Patterson, Thomas F. ;

Maschmeyer, Georg ;

Bille, Jacques ;

Dismukes, William E. ;

Herbrecht, Raoul ;

Hope, William W. ;

Kibbler, Christopher C. ;

Kullberg, Bart Jan ;

Marr, Kieren A. ;

Munoz, Patricia ;

Odds, Frank C. ;

Perfect, John R. ;

Restrepo, Angela ;

Ruhnke, Markus ;

Segal, Brahm H. ;

Sobel, Jack D. ;

Sorrell, Tania C. ;

Viscoli, Claudio ;

Wingard, John R. ;

Zaoutis, Theoklis ;

Bennett, John E. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (12) :1813-1821

[4] Clinical Forms of Dermatophytosis (Ringworm Infection) [J].

Degreef, Hugo .

MYCOPATHOLOGIA, 2008, 166 (5-6) :257-265

[5] Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency [J].

Drewniak, Agata ;

Gazendam, Roel P. ;

Tool, Anton T. J. ;

van Houdt, Michel ;

Jansen, Machiel H. ;

van Hamme, John L. ;

van Leeuwen, Ester M. M. ;

Roos, Dirk ;

Scalais, Emmanuel ;

de Beaufort, Carine ;

Janssen, Hans ;

van den Berg, Timo K. ;

Kuijpers, Taco W. .

BLOOD, 2013, 121 (13) :2385-2392

[6] CARD9 Deficiency and Spontaneous Central Nervous System Candidiasis: Complete Clinical Remission With GM-CSF Therapy [J].

Gavino, Christina ;

Cotter, Anthony ;

Lichtenstein, Daniel ;

Lejtenyi, Duncan ;

Fortin, Claude ;

Legault, Catherine ;

Alirezaie, Najmeh ;

Majewski, Jacek ;

Sheppard, Donald C. ;

Behr, Marcel A. ;

Foulkes, William D. ;

Vinh, Donald C. .

CLINICAL INFECTIOUS DISEASES, 2014, 59 (01) :81-84

[7] A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections [J].

Glocker, Erik-Oliver ;

Hennigs, Andre ;

Nabavi, Mohammad ;

Schaeffer, Alejandro A. ;

Woellner, Cristina ;

Salzer, Ulrich ;

Pfeifer, Dietmar ;

Veelken, Hendrik ;

Warnatz, Klaus ;

Tahami, Fariba ;

Jamal, Sarah ;

Manguiat, Annabelle ;

Rezaei, Nima ;

Amirzargar, Ali Akbar ;

Plebani, Alessandro ;

Hannesschlaeger, Nicole ;

Gross, Olaf ;

Ruland, Juergen ;

Grimbacher, Bodo .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (18) :1727-1735

[8] In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species [J].

Gupta, AK ;

Kohli, Y ;

Batra, R .

MEDICAL MYCOLOGY, 2005, 43 (02) :179-185

[9] The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens [J].

Hsu, Yen-Michael S. ;

Zhang, Yongliang ;

You, Yun ;

Wang, Donghai ;

Li, Hongxiu ;

Duramad, Omar ;

Qin, Xiao-Feng ;

Dong, Chen ;

Lin, Xin .

NATURE IMMUNOLOGY, 2007, 8 (02) :198-205

[10] Determination of Posaconazole Levels in Toenails of Adults with Onychomycosis following Oral Treatment with Four Regimens of Posaconazole for 12 or 24 Weeks [J].

Krishna, Gopal ;

Ma, Lei ;

Martinho, Monika ;

Prasad, Pratapa ;

Wahl, Janice ;

Tavakkol, Amir .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (09) :4424-4426

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