Induced pluripotent stem cells: A new era for hepatology

被引：54
作者：
Asgari, Samira [1 ,2 ]
Pournasr, Behshad [1 ]
Salekdeh, Ghasem Hosseini [3 ,4 ]
Ghodsizadeh, Arefeh [1 ,2 ]
Ott, Michael [5 ,6 ]
Baharvand, Hossein [1 ,7 ]
机构：
[1] ACECR, Royal Inst Stem Cell Biol & Technol, Dept Stem Cells & Dev Biol, Tehran, Iran
[2] Univ Tehran, Coll Sci, Dept Biotechnol, Tehran, Iran
[3] ACECR, Royal Inst Stem Cell Biol & Technol, Dept Mol Syst Biol, Tehran, Iran
[4] Agr Biotechnol Res Inst Iran, Dept Syst Biol, Karaj, Iran
[5] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-3000 Hannover, Germany
[6] Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany
[7] Univ Sci & Culture, ACECR, Dept Dev Biol, Tehran, Iran
来源：
JOURNAL OF HEPATOLOGY | 2010年 / 53卷 / 04期
关键词：
Induced pluripotent stem (iPS) cells; Hepatology; Transplantation; Gene therapy; Bio-artificial livers; Drug development; HEPATOCYTE-LIKE CELLS; ORTHOTOPIC LIVER-TRANSPLANTATION; HIGHLY EFFICIENT DIFFERENTIATION; DENSITY-LIPOPROTEIN RECEPTOR; VIVO GENE-THERAPY; IPS CELLS; BIOARTIFICIAL LIVER; PHASE-I; DIRECTED DIFFERENTIATION; HEPATIC DIFFERENTIATION;
D O I：
10.1016/j.jhep.2010.05.009
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Stem cell transplantation has been proposed as an attractive alternative approach to restore liver mass and function. Recent progress has been reported on the generation of induced pluripotent stem (iPS) cells from somatic cells. Human-iPS cells can be differentiated towards the hepatic lineage which presents possibilities for improving research on diseases, drug development, tissue engineering, the development of bio-artificial livers, and a foundation for producing autologous cell therapies that would avoid immune rejection and enable correction of gene defects prior to cell transplantation. This focused review will discuss how human iPS cell advances are likely to have an impact on hepatology. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：738 / 751
页数：14
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