Pathways of Colorectal Carcinogenesis

被引：369

作者：

Nguyen, Long H. ^{[1
,2
,3
]}

Goel, Ajay ^{[4
,5
,6
]}

Chung, Daniel C. ^{[1
,2
,7
]}

机构：

[1] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA

[4] Baylor Scott & White Res Inst, Ctr Translat Genom & Oncol, Ctr Gastrointestinal Res, Dallas, TX USA

[5] Baylor Univ, Med Ctr, Charles A Sammons Canc Ctr, Dallas, TX USA

[6] City Hope Comprehens Canc Ctr, Beckman Res Inst, Duarte, CA USA

[7] Massachusetts Gen Hosp, Ctr Canc Risk Assessment, Boston, MA 02114 USA

来源：

GASTROENTEROLOGY | 2020年 / 158卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CRC; DNA mismatch repair; genomic instability; serrated polyp; CPG ISLAND METHYLATION; TUMOR MICROSATELLITE-INSTABILITY; SESSILE SERRATED ADENOMAS; ABERRANT CRYPT FOCI; DNA MISMATCH REPAIR; COLON-CANCER; GENE-EXPRESSION; PIK3CA MUTATION; KRAS MUTATIONS; BRAF MUTATION;

D O I：

10.1053/j.gastro.2019.08.059

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Colorectal cancer is a heterogeneous disease that develops via stepwise accumulation of well-characterized genetic and epigenetic alterations. We review the genetic changes associated with the development of precancerous colorectal adenomas and their progression to tumors, as well as the effects of defective DNA repair, chromosome instability, microsatellite instability, and alterations in the serrated pathway and DNA methylation. We provide in-sights into the different molecular subgroups of colorectal tumors that develop via each of these different mechanisms and their associations with patient outcomes.

引用

页码：291 / 302

页数：12

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