Predominance of Gram-negative bacilli among patients with catheter-related bloodstream infections

被引：44

作者：

Braun, E. ^{[1
]}

Hussein, K. ^{[2
]}

Geffen, Y. ^{[3
]}

Rabino, G. ^{[2
]}

Bar-Lavie, Y. ^{[4
]}

Paul, M. ^{[2
]}

机构：

[1] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Rambam Hlth Care Campus, Med H, IL-31096 Haifa, Israel

[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Rambam Hlth Care Campus, Div Infect Dis, IL-31096 Haifa, Israel

[3] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Rambam Hlth Care Campus, Microbiol Lab, IL-31096 Haifa, Israel

[4] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Rambam Hlth Care Campus, Intens Care Unit, IL-31096 Haifa, Israel

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 10期

关键词：

Acinetobacter; catheter-related bacteraemia; central venous catheter; Klebsiella; CHANGING EPIDEMIOLOGY; INCREASING PREVALENCE; SAFETY;

D O I：

10.1111/1469-0691.12565

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We evaluated changes in the epidemiology of catheter-related bloodstream infections (CRBSIs) between 1996 and 2012 in a tertiary care centre in Israel. The cohort included 1754 episodes of CRBSI. The incidence of CRBSIs decreased throughout the study period, whereas 30-day mortality following bacteraemia increased. There was a linear shift toward predominance of Gram-negative bacilli throughout the study period (p for trend<0.001). In 1996, 68% (68/100) of CRBSIs were caused by Gram-positive cocci, whereas in 2012 77.8% (28/26) were caused by Gram-negative bacilli. The shift towards Gram-negative CRBSIs and the associated mortality mandates that empirical treatment for CRBSIs be directed by local epidemiology.

引用

页码：O627 / O629

页数：3

共 10 条

[1] Catheter-related bloodstream infections caused by Gram-negative bacteria [J].

Bouza, E. ;

Eworo, A. ;

Fernandez Cruz, A. ;

Reigadas, E. ;

Rodriguez-Creixems, M. ;

Munoz, P. .

JOURNAL OF HOSPITAL INFECTION, 2013, 85 (04) :316-320

[2] Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Annual Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007 [J].

Hidron, Alicia I. ;

Edwards, Jonathan R. ;

Patel, Jean ;

Horan, Teresa C. ;

Sievert, Dawn M. ;

Pollock, Daniel A. ;

Fridkin, Scott K. .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2008, 29 (11) :996-1011

[3]

Isenberg HD, 2004, Clinical microbiology procedures handbook, V2nd

[4] Changing epidemiology of central venous catheter-related bloodstream infections: increasing prevalence of Gram-negative pathogens [J].

Marcos, Miguel ;

Soriano, Alex ;

Inurrieta, Amaia ;

Martinez, Jose A. ;

Romero, Alberto ;

Cobos, Nazaret ;

Hernandez, Cristina ;

Almela, Manel ;

Marco, Francesc ;

Mensa, Josep .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (09) :2119-2125

[5]

O'Grady NP, 2011, CLIN INFECT DIS, V52, pE162, DOI [10.1016/j.ajic.2011.01.003, 10.1093/cid/cir257]

[6] Systematic Review and Meta-Analysis of the Efficacy of Appropriate Empiric Antibiotic Therapy for Sepsis [J].

Paul, Mical ;

Shani, Vered ;

Muchtar, Eli ;

Kariv, Galia ;

Robenshtok, Eyal ;

Leibovici, Leonard .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (11) :4851-4863

[7] Effectiveness and safety of colistin: prospective comparative cohort study [J].

Paul, Mical ;

Bishara, Jihad ;

Levcovich, Ariela ;

Chowers, Michal ;

Goldberg, Elad ;

Singer, Pierre ;

Lev, Shaul ;

Leon, Perla ;

Raskin, Maria ;

Yahav, Dafna ;

Leibovici, Leonard .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (05) :1019-1027

[8] Evolution and aetiological shift of catheter-related bloodstream infection in a whole institution: the microbiology department may act as a watchtower [J].

Rodriguez-Creixems, M. ;

Munoz, P. ;

Martin-Rabadan, P. ;

Cercenado, E. ;

Guembe, M. ;

Bouza, E. .

CLINICAL MICROBIOLOGY AND INFECTION, 2013, 19 (09) :845-851

[9] Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010 [J].

Sievert, Dawn M. ;

Ricks, Philip ;

Edwards, Jonathan R. ;

Schneider, Amy ;

Patel, Jean ;

Srinivasan, Arjun ;

Kallen, Alex ;

Limbago, Brandi ;

Fridkin, Scott .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2013, 34 (01) :1-14

[10] Comment on: Changing epidemiology of central venous catheter-related bloodstream infections: increasing prevalence of Gram-negative pathogens [J].

Sorde, Roger ;

Almirante, Benito ;

Palomar, Mercedes ;

Pahissa, Albert .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (06) :1565-1566

← 1 →