Nickel-catalyzed electrochemical Minisci acylation of aromatic N-heterocycles with α-keto acids via ligand-to-metal electron transfer pathway

被引：46

作者：

Ding, Hang ^{[1
]}

Xu, Kun ^{[1
]}

Zeng, Cheng-Chu ^{[1
]}

机构：

[1] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing Key Lab Environm & Viral Oncol, Beijing 100124, Peoples R China

来源：

JOURNAL OF CATALYSIS | 2020年 / 381卷 / 381期

基金：

中国国家自然科学基金;

关键词：

Minisci acylation reactions; Nickel-catalysis; alpha-Keto acid; Electrosynthesis; DECARBOXYLATIVE ACYLATION; REDOX CATALYSTS; HETEROARENES; CYCLIZATION; RADICALS; NITROGEN;

D O I：

10.1016/j.jcat.2019.10.030

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A nickel-catalyzed electrochemical methodology for the Minisci acylation of aromatic electron-deficient heterocycles with alpha-keto acids has been developed. The reaction is performed in an undivided cell under constant current conditions, featuring broad scope of substrates and avoiding the conventional utilization of silver-based catalysts in conjunction with excess amount of oxidants. Cyclic voltammetric analysis disclosed that a ligand-to-metal electron transfer process may be involved in the generation of the key acyl radicals. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：38 / 43

页数：6

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