Glutaminolysis as a target for cancer therapy

被引：336

作者：

Jin, L. ^{[1
]}

Alesi, G. N. ^{[1
]}

Kang, S. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA USA

来源：

ONCOGENE | 2016年 / 35卷 / 28期

关键词：

KIDNEY-TYPE GLUTAMINASE; GLUTAMATE-DEHYDROGENASE; OXIDATIVE STRESS; REDUCTIVE CARBOXYLATION; CELL-PROLIFERATION; BREAST-CANCER; METABOLISM; GROWTH; GLUCOSE; GLYCOLYSIS;

D O I：

10.1038/onc.2015.447

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in these metabolic processes could provide novel approaches to improve cancer treatment. This review summarizes current findings on the role of glutaminolytic enzymes in human cancers and provides an update on the development of small molecule inhibitors to target glutaminolysis for cancer therapy.

引用

页码：3619 / 3625

页数：7

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