mRNA helicases: the tacticians of translational control

被引：250

作者：

Parsyan, Armen ^{[1
,3
]}

Svitkin, Yuri ^{[1
,3
]}

Shahbazian, David ^{[2
]}

Gkogkas, Christos ^{[1
,3
]}

Lasko, Paul ^{[4
,5
]}

Merrick, William C. ^{[6
]}

Sonenberg, Nahum ^{[1
,3
]}

机构：

[1] McGill Univ, Fac Med, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada

[2] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06511 USA

[3] McGill Univ, Fac Med, Dept Biochem, Montreal, PQ H3A 1A3, Canada

[4] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada

[5] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1B1, Canada

[6] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 04期

基金：

加拿大健康研究院;

关键词：

DEAD-BOX PROTEINS; INITIATION-FACTOR; 4B; CAP-DEPENDENT TRANSLATION; EXON JUNCTION COMPLEX; FACTOR 4G EIF4G; EUKARYOTIC TRANSLATION; FACTOR; 4A; SACCHAROMYCES-CEREVISIAE; KINETIC CHARACTERIZATION; MAMMALIAN TRANSLATION;

D O I：

10.1038/nrm3083

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The translation initiation step in eukaryotes is highly regulated and rate-limiting. During this process, the 40S ribosomal subunit is usually recruited to the 5' terminus of the mRNA. It then migrates towards the initiation codon, where it is joined by the 60S ribosomal subunit to form the 80S initiation complex. Secondary structures in the 5' untranslated region (UTR) can impede binding and movement of the 40S ribosome. The canonical eukaryotic translation initiation factor eIF4A (also known as DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR. Growing evidence suggests that other helicases are also important for translation initiation and may promote the scanning processivity of the 40S subunit, synergize with eIF4A to 'melt' secondary structures or facilitate translation of a subset of mRNAs.

引用

页码：235 / 245

页数：11

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