Proline-Derived Aminotriazole Ligands: Preparation and Use in the Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation

被引：39

作者：

Cambeiro, Xacobe C. ^{[1
,2
]}

Pericas, Miquel A. ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, E-43007 Tarragona, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 01期

关键词：

asymmetric catalysis; click chemistry; hydrogen transfer; proline; ruthenium; triazoles; ENANTIOSELECTIVE MICHAEL ADDITION; CLICK-CHEMISTRY; 1,3-DIPOLAR CYCLOADDITIONS; RECYCLABLE ORGANOCATALYST; PYRROLIDINE-TRIAZOLE; SUPPORTED ORGANOCATALYST; CONTINUOUS-FLOW; CHIRAL LIGANDS; KETONES; POLYMER;

D O I：

10.1002/adsc.201000678

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The preparation of 2-triazolyl- and 2-triazolylmethylpyrrolidines from L-proline and L-trans-4-hydroxyproline is described, along with their evaluation as chiral ligands in ruthenium-catalyzed asymmetric transfer hydrogenation. Modular evolution of the ligands by introduction of remote substituents is also presented, showing a surprisingly important effect on the performance of the ligands.

引用

页码：113 / 124

页数：12

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