Bioreactor Technology for Cell Therapy Manufacturing in Regenerative Medicine

被引：5
作者：
Zhang, Hu [1 ]
Kent, David E. [1 ]
Albanna, Mohammad [2 ]
Lhu, Lexan [3 ]
Sun, Xiuzhi Susan [4 ]
Eaker, Shannon [5 ]
Somara, Sita [6 ]
机构：
[1] Keck Grad Inst, Henry E Riggs Sch Appl Life Sci, 535 Watson Dr, Claremont, CA 91717 USA
[2] Humabiologics Inc, 275 N Gateway Dr, Phoenix, AZ 85034 USA
[3] PBS Biotech Inc, Camarillo, CA USA
[4] Kansas State Univ, Dept Grain Sci & Ind, 1980 Kimble Ave, Manhattan, KS 66506 USA
[5] 100 Results Way, Marlborough, MA 01752 USA
[6] Vigene Biosci, 5 Res Court, Rockville, MD 20850 USA
来源：
CURRENT STEM CELL REPORTS | 2021年 / 7卷 / 04期
关键词：
3D cell culture; Microcarrier; Hollow fiber; Matrix protein; Regenerative medicine; Bioreactors; MESENCHYMAL STROMAL CELLS; SINGLE-USE BIOREACTORS; STEM-CELLS; SCALE-UP; EXPANSION; CULTURE;
D O I：
10.1007/s40778-021-00200-x
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Purpose of Review It is a great challenge to scale up current cell therapy processes developed in 2D systems, and bioreactor technology could play an essential role in the scale-up of cell therapeutic products. Recent Findings Cell quality is critical to the therapeutic efficacy and their critical quality attributes (CQAs) are tightly related to their manufacturing processes. Employment of appropriate bioreactors for cellular products would enhance the productivity, reduce the cost as well as ensure the product CQAs. Summary The article reviews current commercially available bioreactors and their applications for regenerative therapeutic products. Regulatory, quality, and manufacturing aspects of these bioreactors are discussed.
引用
收藏
页码：212 / 218
页数：7
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